Early Childhood Neurocognition in Relation to Middle Childhood Psychotic Experiences in Children at Familial High Risk of Schizophrenia or Bipolar Disorder and Population-Based Controls: The Danish High Risk and Resilience Study
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Early Childhood Neurocognition in Relation to Middle Childhood Psychotic Experiences in Children at Familial High Risk of Schizophrenia or Bipolar Disorder and Population-Based Controls : The Danish High Risk and Resilience Study. / Knudsen, Christina Bruun; Hemager, Nicoline; Jepsen, Jens Richardt Mollegaard; Gregersen, Maja; Greve, Aja Neergaard; Andreassen, Anna Krogh; Veddum, Lotte; Brandt, Julie Marie; Krantz, Mette Falkenberg; Sondergaard, Anne; Burton, Birgitte Klee; Thorup, Anne Amalie Elgaard; Nordentoft, Merete; Lambek, Rikke; Mors, Ole; Bliksted, Vibeke Fuglsang.
In: Schizophrenia Bulletin, Vol. 49, No. 3, 2023, p. 756-767.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Early Childhood Neurocognition in Relation to Middle Childhood Psychotic Experiences in Children at Familial High Risk of Schizophrenia or Bipolar Disorder and Population-Based Controls
T2 - The Danish High Risk and Resilience Study
AU - Knudsen, Christina Bruun
AU - Hemager, Nicoline
AU - Jepsen, Jens Richardt Mollegaard
AU - Gregersen, Maja
AU - Greve, Aja Neergaard
AU - Andreassen, Anna Krogh
AU - Veddum, Lotte
AU - Brandt, Julie Marie
AU - Krantz, Mette Falkenberg
AU - Sondergaard, Anne
AU - Burton, Birgitte Klee
AU - Thorup, Anne Amalie Elgaard
AU - Nordentoft, Merete
AU - Lambek, Rikke
AU - Mors, Ole
AU - Bliksted, Vibeke Fuglsang
PY - 2023
Y1 - 2023
N2 - Background and Hypothesis Familial high-risk (FHR) studies examining longitudinal associations between neurocognition and psychotic experiences are currently lacking. We hypothesized neurocognitive impairments at age 7 to be associated with increased risk of psychotic experiences from age 7 to 11 in children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and population-based controls (PBC), and further, impaired functioning in some neurocognitive functions to be associated with greater risk of psychotic experiences in children at FHR-SZ or FHR-BP relative to PBC. Study Design Neurocognition was assessed at age 7 (early childhood) and psychotic experiences from age 7 to 11 (middle childhood) in 449 children from the Danish High Risk and Resilience Study. The neurocognitive assessment covered intelligence, processing speed, attention, visuospatial and verbal memory, working memory, and set-shifting. Psychotic experiences were assessed through face-to-face interviews with the primary caregiver and the child. Study Results Set-shifting impairments at age 7 were associated with greater risk of psychotic experiences from age 7 to 11 in children at FHR-SZ. Children at FHR-BP and PBC showed no differential associations. Working memory and visuospatial memory impairments were related to increased risk of psychotic experiences across the cohort. However, adjusting for concurrent psychopathology attenuated these findings. Conclusions Early childhood neurocognitive impairments are risk markers of middle childhood psychotic experiences, of which impaired set-shifting appears to further increase the risk of psychotic experiences in children at FHR-SZ. More research is needed to examine longitudinal associations between neurocognitive impairments and psychotic experiences in FHR samples.
AB - Background and Hypothesis Familial high-risk (FHR) studies examining longitudinal associations between neurocognition and psychotic experiences are currently lacking. We hypothesized neurocognitive impairments at age 7 to be associated with increased risk of psychotic experiences from age 7 to 11 in children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and population-based controls (PBC), and further, impaired functioning in some neurocognitive functions to be associated with greater risk of psychotic experiences in children at FHR-SZ or FHR-BP relative to PBC. Study Design Neurocognition was assessed at age 7 (early childhood) and psychotic experiences from age 7 to 11 (middle childhood) in 449 children from the Danish High Risk and Resilience Study. The neurocognitive assessment covered intelligence, processing speed, attention, visuospatial and verbal memory, working memory, and set-shifting. Psychotic experiences were assessed through face-to-face interviews with the primary caregiver and the child. Study Results Set-shifting impairments at age 7 were associated with greater risk of psychotic experiences from age 7 to 11 in children at FHR-SZ. Children at FHR-BP and PBC showed no differential associations. Working memory and visuospatial memory impairments were related to increased risk of psychotic experiences across the cohort. However, adjusting for concurrent psychopathology attenuated these findings. Conclusions Early childhood neurocognitive impairments are risk markers of middle childhood psychotic experiences, of which impaired set-shifting appears to further increase the risk of psychotic experiences in children at FHR-SZ. More research is needed to examine longitudinal associations between neurocognitive impairments and psychotic experiences in FHR samples.
KW - severe mental illness
KW - preadolescence
KW - psychosis
KW - cognitive functions
KW - CROSS-NATIONAL ANALYSIS
KW - 7-YEAR-OLD CHILDREN
KW - COMMUNITY SAMPLE
KW - 1ST-EPISODE SCHIZOPHRENIA
KW - COGNITIVE-DEVELOPMENT
KW - ADULT SCHIZOPHRENIA
KW - PROCESSING SPEED
KW - WORKING-MEMORY
KW - COMPLEX FIGURE
KW - METAANALYSIS
U2 - 10.1093/schbul/sbac198
DO - 10.1093/schbul/sbac198
M3 - Journal article
C2 - 36548470
VL - 49
SP - 756
EP - 767
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
SN - 0586-7614
IS - 3
ER -
ID: 344977605