Differential effects of bile acids on the postprandial secretion of gut hormones: A randomized crossover study
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Differential effects of bile acids on the postprandial secretion of gut hormones : A randomized crossover study. / McGlone, Emma Rose; Malallah, Khalefah; Cuenco, Joyceline; Wewer Albrechtsen, Nicolai J.; Holst, Jens J.; Vincent, Royce P.; Ling, Charlotte; Khan, Omar A.; Verma, Surabhi; Ahmed, Ahmed R.; Walters, Julian R.F.; Khoo, Bernard; Bloom, Stephen R.; Tan, Tricia M.M.
In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 320, No. 4, 2021, p. E671-E679.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Differential effects of bile acids on the postprandial secretion of gut hormones
T2 - A randomized crossover study
AU - McGlone, Emma Rose
AU - Malallah, Khalefah
AU - Cuenco, Joyceline
AU - Wewer Albrechtsen, Nicolai J.
AU - Holst, Jens J.
AU - Vincent, Royce P.
AU - Ling, Charlotte
AU - Khan, Omar A.
AU - Verma, Surabhi
AU - Ahmed, Ahmed R.
AU - Walters, Julian R.F.
AU - Khoo, Bernard
AU - Bloom, Stephen R.
AU - Tan, Tricia M.M.
PY - 2021
Y1 - 2021
N2 - Bile acids (BA) regulate postprandial metabolism directly and indirectly by affecting the secretion of gut hormones like glucagon-like peptide-1 (GLP-1). The postprandial effects of BA on the secretion of other metabolically active hormones are not well understood. The objective of this study was to investigate the effects of oral ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) on postprandial secretion of GLP-1, oxyntomodulin (OXM), peptide YY (PYY), glucose-dependent insulinotropic peptide (GIP), glucagon, and ghrelin. Twelve healthy volunteers underwent a mixed meal test 60min after ingestion of UDCA (12-16mg/kg), CDCA (13-16mg/ kg), or no BA in a randomized crossover study. Glucose, insulin, GLP-1, OXM, PYY, GIP, glucagon, ghrelin, and fibroblast growth factor 19 were measured prior to BA administration at -60 and 0 min (just prior to mixed meal) and 15, 30, 60, 120, 180, and 240min after the meal. UDCA and CDCA provoked differential gut hormone responses; UDCA did not have any significant effects, but CDCA provoked significant increases in GLP-1 and OXM and a profound reduction in GIP. CDCA increased fasting GLP-1 and OXM secretion in parallel with an increase in insulin. On the other hand, CDCA reduced postprandial secretion of GIP, with an associated reduction in postprandial insulin secretion. Exogenous CDCA can exert multiple salutary effects on the secretion of gut hormones; if these effects are confirmed in obesity and type 2 diabetes, CDCA may be a potential therapy for these conditions.
AB - Bile acids (BA) regulate postprandial metabolism directly and indirectly by affecting the secretion of gut hormones like glucagon-like peptide-1 (GLP-1). The postprandial effects of BA on the secretion of other metabolically active hormones are not well understood. The objective of this study was to investigate the effects of oral ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) on postprandial secretion of GLP-1, oxyntomodulin (OXM), peptide YY (PYY), glucose-dependent insulinotropic peptide (GIP), glucagon, and ghrelin. Twelve healthy volunteers underwent a mixed meal test 60min after ingestion of UDCA (12-16mg/kg), CDCA (13-16mg/ kg), or no BA in a randomized crossover study. Glucose, insulin, GLP-1, OXM, PYY, GIP, glucagon, ghrelin, and fibroblast growth factor 19 were measured prior to BA administration at -60 and 0 min (just prior to mixed meal) and 15, 30, 60, 120, 180, and 240min after the meal. UDCA and CDCA provoked differential gut hormone responses; UDCA did not have any significant effects, but CDCA provoked significant increases in GLP-1 and OXM and a profound reduction in GIP. CDCA increased fasting GLP-1 and OXM secretion in parallel with an increase in insulin. On the other hand, CDCA reduced postprandial secretion of GIP, with an associated reduction in postprandial insulin secretion. Exogenous CDCA can exert multiple salutary effects on the secretion of gut hormones; if these effects are confirmed in obesity and type 2 diabetes, CDCA may be a potential therapy for these conditions.
KW - Bile acid
KW - Glucagon-like peptides
KW - Gut hormones
KW - Neuroendocrine cells
U2 - 10.1152/AJPENDO.00580.2020
DO - 10.1152/AJPENDO.00580.2020
M3 - Journal article
C2 - 33459181
AN - SCOPUS:85103608110
VL - 320
SP - E671-E679
JO - A J P: Endocrinology and Metabolism (Online)
JF - A J P: Endocrinology and Metabolism (Online)
SN - 1522-1555
IS - 4
ER -
ID: 260351701