TY - JOUR

T1 - Different Tc response profiles are associated with survival in the murine lymphocytic choriomeningitis virus infection

AU - Thomsen, Allan Randrup

AU - Marker, O

AU - Pfau, C J

N1 - Keywords: Animals; Female; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred Strains; T-Lymphocytes, Cytotoxic; Virus Activation

PY - 1987

Y1 - 1987

N2 - The pathogenicity of lymphocytic choriomeningitis virus (LCMV) inoculated intracerebrally (i.c.) varies with virus strain and dose as well as with the mouse strain used as host. Recently, results have indicated that susceptibility to lethal disease correlates directly the ability of the host to produce early and high virus-specific Tc activity. However, in the present studies we demonstrate that even though this holds true in many mouse/virus combinations, it does not apply in others. Thus, in C3H mice infected with (moderately) high doses of Traub strain LCMV, early and high Tc activity was found despite a mortality rate of only 10-20%. Similarly, in C3H mice inoculated with the aggressive and docile substrains of UBC strain LCMV, which differ markedly in their pathogenicity for this mouse strain, similar kinetics of Tc induction were observed. Finally, in DBA/2 mice which do not die following infection with the otherwise lethal aggressive substrain, Tc induction could be found to be as efficient as in BALB/c mice, all of which die from acute LCM disease when infected with this virus isolate. The results indicate, therefore, that early and high Tc activity does not constitute a sufficient prerequisite for lethal disease, and that different Tc response profiles may be associated with low mortality following i.c. inoculation with LCMV.

AB - The pathogenicity of lymphocytic choriomeningitis virus (LCMV) inoculated intracerebrally (i.c.) varies with virus strain and dose as well as with the mouse strain used as host. Recently, results have indicated that susceptibility to lethal disease correlates directly the ability of the host to produce early and high virus-specific Tc activity. However, in the present studies we demonstrate that even though this holds true in many mouse/virus combinations, it does not apply in others. Thus, in C3H mice infected with (moderately) high doses of Traub strain LCMV, early and high Tc activity was found despite a mortality rate of only 10-20%. Similarly, in C3H mice inoculated with the aggressive and docile substrains of UBC strain LCMV, which differ markedly in their pathogenicity for this mouse strain, similar kinetics of Tc induction were observed. Finally, in DBA/2 mice which do not die following infection with the otherwise lethal aggressive substrain, Tc induction could be found to be as efficient as in BALB/c mice, all of which die from acute LCM disease when infected with this virus isolate. The results indicate, therefore, that early and high Tc activity does not constitute a sufficient prerequisite for lethal disease, and that different Tc response profiles may be associated with low mortality following i.c. inoculation with LCMV.

M3 - Journal article

C2 - 3496657

VL - 25

SP - 637

EP - 644

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

SN - 0301-6323

IS - 6

ER -