TY - JOUR

T1 - Dietary magnesium and cardiovascular disease

T2 - A review with emphasis in epidemiological studies

AU - Rosique-Esteban, Nuria

AU - Guasch-Ferré, Marta

AU - Hernández-Alonso, Pablo

AU - Salas-Salvadó, Jordi

N1 - Publisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2018

Y1 - 2018

N2 - Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The present review aims to summarize recent scientific evidence on the topic, with a focus on data from epidemiological studies assessing the associations between Mg intake and major cardiovascular (CV) risk factors and CVD. We also aimed to review current literature on circulating Mg and CVD, as well as potential biological processes underlying these observations. We concluded that high Mg intake is associated with lower risk of major CV risk factors (mainly metabolic syndrome, diabetes and hypertension), stroke and total CVD. Higher levels of circulating Mg are associated with lower risk of CVD, mainly ischemic heart disease and coronary heart disease. Further, RCTs and prospective studies would help to clarify whether Mg intake and Mg circulating levels may also protect against other CVDs and CVD death.

AB - Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The present review aims to summarize recent scientific evidence on the topic, with a focus on data from epidemiological studies assessing the associations between Mg intake and major cardiovascular (CV) risk factors and CVD. We also aimed to review current literature on circulating Mg and CVD, as well as potential biological processes underlying these observations. We concluded that high Mg intake is associated with lower risk of major CV risk factors (mainly metabolic syndrome, diabetes and hypertension), stroke and total CVD. Higher levels of circulating Mg are associated with lower risk of CVD, mainly ischemic heart disease and coronary heart disease. Further, RCTs and prospective studies would help to clarify whether Mg intake and Mg circulating levels may also protect against other CVDs and CVD death.

KW - Cardiovascular

KW - Death

KW - Epidemiological studies

KW - Inflammation

KW - Magnesium

KW - Metabolic syndrome

KW - Mortality

KW - Oxidation

KW - Type 2 diabetes

U2 - 10.3390/nu10020168

DO - 10.3390/nu10020168

M3 - Review

C2 - 29389872

AN - SCOPUS:85041579943

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 2

M1 - 168

ER -