Diagnostic yield of high-density versus low-density EEG: The effect of spatial sampling, timing and duration of recording
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Diagnostic yield of high-density versus low-density EEG : The effect of spatial sampling, timing and duration of recording. / Bach Justesen, Anders; Foged, Mette Thrane; Fabricius, Martin; Skaarup, Christian; Hamrouni, Nizar; Martens, Terje; Paulson, Olaf B.; Pinborg, Lars H.; Beniczky, Sándor.
In: Clinical Neurophysiology, Vol. 130, No. 11, 2019, p. 2060-2064.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Diagnostic yield of high-density versus low-density EEG
T2 - The effect of spatial sampling, timing and duration of recording
AU - Bach Justesen, Anders
AU - Foged, Mette Thrane
AU - Fabricius, Martin
AU - Skaarup, Christian
AU - Hamrouni, Nizar
AU - Martens, Terje
AU - Paulson, Olaf B.
AU - Pinborg, Lars H.
AU - Beniczky, Sándor
PY - 2019
Y1 - 2019
N2 - Objective: To investigate the effect of spatial sampling and of recording duration on the diagnostic yield of EEG for identification of interictal epileptiform discharges (IEDs). Previous studies demonstrated that high-density (HD) recordings increased accuracy of localization compared to low-density (LD) recordings. Methods: We have prospectively evaluated the effect of spatial sampling and of recording duration in patients who had short-term (ST) recordings with a HD array of 256 electrodes following long-term (LT) recordings with a LD array consisting of the standard IFCN array of 25 electrodes. IED clusters were identified in four datasets: LT-LD, ST-LD (spatially down-sampled to the standard IFCN array), ST-HD and a shortened (90 minutes) epoch of LT-LD. Results: Sixty consecutive patients were recruited. We identified 89 IED clusters totally. Two clusters were found by increasing spatial sampling from 25 to 256 electrodes. This modest increase was not statistically significant. Eight clusters were missed by reducing the recording duration to 90 minutes, as compared with the LT recordings (p = 0.003). Conclusions: Recording duration is more important for the diagnostic yield of EEGs than increasing spatial sampling beyond the standard IFCN electrode array. Significance: The standard IFCN electrode array provides sufficient spatial sampling for identification of the IEDs.
AB - Objective: To investigate the effect of spatial sampling and of recording duration on the diagnostic yield of EEG for identification of interictal epileptiform discharges (IEDs). Previous studies demonstrated that high-density (HD) recordings increased accuracy of localization compared to low-density (LD) recordings. Methods: We have prospectively evaluated the effect of spatial sampling and of recording duration in patients who had short-term (ST) recordings with a HD array of 256 electrodes following long-term (LT) recordings with a LD array consisting of the standard IFCN array of 25 electrodes. IED clusters were identified in four datasets: LT-LD, ST-LD (spatially down-sampled to the standard IFCN array), ST-HD and a shortened (90 minutes) epoch of LT-LD. Results: Sixty consecutive patients were recruited. We identified 89 IED clusters totally. Two clusters were found by increasing spatial sampling from 25 to 256 electrodes. This modest increase was not statistically significant. Eight clusters were missed by reducing the recording duration to 90 minutes, as compared with the LT recordings (p = 0.003). Conclusions: Recording duration is more important for the diagnostic yield of EEGs than increasing spatial sampling beyond the standard IFCN electrode array. Significance: The standard IFCN electrode array provides sufficient spatial sampling for identification of the IEDs.
KW - Diagnostic yield
KW - Duration
KW - EEG
KW - High-density array
KW - Interictal epileptiform discharges
KW - Spatial sampling
U2 - 10.1016/j.clinph.2019.08.007
DO - 10.1016/j.clinph.2019.08.007
M3 - Journal article
C2 - 31541983
AN - SCOPUS:85072240797
VL - 130
SP - 2060
EP - 2064
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 11
ER -
ID: 231896683