Development of obesity and polycystic ovary syndrome in adolescents
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Development of obesity and polycystic ovary syndrome in adolescents. / Vilmann, Lea S; Thisted, Ebbe; Baker, Jennifer L; Holm, Jens-Christian.
In: Hormone Research in Paediatrics, Vol. 78, No. 5-6, 2012, p. 269-78.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Development of obesity and polycystic ovary syndrome in adolescents
AU - Vilmann, Lea S
AU - Thisted, Ebbe
AU - Baker, Jennifer L
AU - Holm, Jens-Christian
N1 - Copyright © 2012 S. Karger AG, Basel.
PY - 2012
Y1 - 2012
N2 - Obesity in adolescents is prevalent worldwide. Polycystic ovary syndrome (PCOS) is often associated with obesity in women, and it has serious metabolic and reproductive health implications. Although PCOS does not become clinically visible until early adolescence, its origins are likely much earlier. Therefore, we reviewed the recent literature regarding the mechanisms linking the development of PCOS and obesity in adolescent girls. We found that excess abdominal adipose tissue (AT) initiates metabolic and endocrine aberrations that are central in the progression of PCOS. As an example, abdominal AT impairs insulin action, which interacts with the progression of hyperandrogenism. In addition, excessive androgen levels lead to impaired glucose uptake, which also contributes to insulin resistance, which again increases the deposition of visceral fat. The body composition is influenced by testosterone, which decreases subcutaneous fat lipolysis and influences adipocyte distribution. These mechanisms may explain why PCOS girls have an increased visceral adipose mass independent of body mass index. Therefore, first-line treatment in adolescent PCOS is often lifestyle intervention to prevent the damaging effects of obesity. Pharmacological treatment of adolescent PCOS is not standardized because the long-term effects in adolescents have not yet been evaluated; therefore, drugs should be prescribed cautiously. Although the complex metabolic interrelationships between obesity and PCOS have yet to be fully understood, the co-occurrence of these conditions in adolescent girls tends to increase the severity of the negative health consequences of each condition.
AB - Obesity in adolescents is prevalent worldwide. Polycystic ovary syndrome (PCOS) is often associated with obesity in women, and it has serious metabolic and reproductive health implications. Although PCOS does not become clinically visible until early adolescence, its origins are likely much earlier. Therefore, we reviewed the recent literature regarding the mechanisms linking the development of PCOS and obesity in adolescent girls. We found that excess abdominal adipose tissue (AT) initiates metabolic and endocrine aberrations that are central in the progression of PCOS. As an example, abdominal AT impairs insulin action, which interacts with the progression of hyperandrogenism. In addition, excessive androgen levels lead to impaired glucose uptake, which also contributes to insulin resistance, which again increases the deposition of visceral fat. The body composition is influenced by testosterone, which decreases subcutaneous fat lipolysis and influences adipocyte distribution. These mechanisms may explain why PCOS girls have an increased visceral adipose mass independent of body mass index. Therefore, first-line treatment in adolescent PCOS is often lifestyle intervention to prevent the damaging effects of obesity. Pharmacological treatment of adolescent PCOS is not standardized because the long-term effects in adolescents have not yet been evaluated; therefore, drugs should be prescribed cautiously. Although the complex metabolic interrelationships between obesity and PCOS have yet to be fully understood, the co-occurrence of these conditions in adolescent girls tends to increase the severity of the negative health consequences of each condition.
KW - Abdominal Fat
KW - Adolescent
KW - Animals
KW - Female
KW - Humans
KW - Hyperandrogenism
KW - Insulin
KW - Insulin Resistance
KW - Obesity
KW - Polycystic Ovary Syndrome
KW - Young Adult
U2 - 10.1159/000345310
DO - 10.1159/000345310
M3 - Journal article
C2 - 23208318
VL - 78
SP - 269
EP - 278
JO - Hormone Research in Paediatrics
JF - Hormone Research in Paediatrics
SN - 1663-2818
IS - 5-6
ER -
ID: 47680999