Determination of albumin transport rate between plasma and peritoneal space in decompensated cirrhosis
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Determination of albumin transport rate between plasma and peritoneal space in decompensated cirrhosis. / Ring-Larsen, H; Henriksen, Jens Henrik Sahl.
In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 44, No. 2, 1984, p. 143-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Determination of albumin transport rate between plasma and peritoneal space in decompensated cirrhosis
AU - Ring-Larsen, H
AU - Henriksen, Jens Henrik Sahl
N1 - Keywords: Adult; Animals; Ascitic Fluid; Blood Volume; Female; Humans; Kinetics; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Serum Albumin; Swine
PY - 1984
Y1 - 1984
N2 - Plasma-to-peritoneal transport rate of albumin (TERperit.space) was determined in eighteen patients with decompensated cirrhosis by sampling ascitic fluid after i.v. injection of 125I-labelled serum albumin. Median TERperit.space was 0.30% of the intravascular albumin mass (IVM) per hour (range 0.10-0.59). The transport rate of albumin from ascitic fluid back to plasma was measured in eight patients by plasma sampling after intraperitoneal injection of 131I-labelled serum albumin. After correction for tracer re-extravasation this back transport (median 0.31, range 0.07-0.44% IVM/h-1) was not significantly different from the simultaneously determined TERperit.space, indicating steady state with respect to albumin flux. Analysis of errors of the method was performed from experiments in pigs, and it is concluded that especially a high content of non-protein bound iodine and even minor bleeding from the abdominal puncture may lead to overestimation of TERperit.space, whereas systematic understimation seems less likely. This may besides differences in patient selection and unsteady state, account for the discrepancy between the present relatively low value and earlier reports on much higher values of TERperit.space in cirrhosis.
AB - Plasma-to-peritoneal transport rate of albumin (TERperit.space) was determined in eighteen patients with decompensated cirrhosis by sampling ascitic fluid after i.v. injection of 125I-labelled serum albumin. Median TERperit.space was 0.30% of the intravascular albumin mass (IVM) per hour (range 0.10-0.59). The transport rate of albumin from ascitic fluid back to plasma was measured in eight patients by plasma sampling after intraperitoneal injection of 131I-labelled serum albumin. After correction for tracer re-extravasation this back transport (median 0.31, range 0.07-0.44% IVM/h-1) was not significantly different from the simultaneously determined TERperit.space, indicating steady state with respect to albumin flux. Analysis of errors of the method was performed from experiments in pigs, and it is concluded that especially a high content of non-protein bound iodine and even minor bleeding from the abdominal puncture may lead to overestimation of TERperit.space, whereas systematic understimation seems less likely. This may besides differences in patient selection and unsteady state, account for the discrepancy between the present relatively low value and earlier reports on much higher values of TERperit.space in cirrhosis.
M3 - Journal article
C2 - 6719019
VL - 44
SP - 143
EP - 149
JO - Scandinavian Journal of Clinical & Laboratory Investigation
JF - Scandinavian Journal of Clinical & Laboratory Investigation
SN - 0036-5513
IS - 2
ER -
ID: 19345058