Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: A systematic review
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Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients : A systematic review. / Kjær, Eva Kristine Ruud; Vase, Christian Bach; Rossing, Maria; Ahlborn, Lise Barlebo; Hjalgrim, Lisa Lyngsie.
In: Translational Oncology, Vol. 34, 101690, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients
T2 - A systematic review
AU - Kjær, Eva Kristine Ruud
AU - Vase, Christian Bach
AU - Rossing, Maria
AU - Ahlborn, Lise Barlebo
AU - Hjalgrim, Lisa Lyngsie
N1 - Publisher Copyright: © 2023
PY - 2023
Y1 - 2023
N2 - Background: Detection of circulating tumor-derived material (cTM) in the peripheral blood (PB) of cancer patients has been shown to be useful in early diagnosis, prediction of prognosis, and disease monitoring. However, it has not yet been thoroughly evaluated for pediatric sarcoma patients. Methods: We searched the PubMed and EMBASE databases for studies reporting the detection of circulating tumor cells, circulating tumor DNA, and circulating RNA in PB of pediatric sarcoma patients. Data on performance in identifying cTM and its applicability in diagnosis, and evaluation of tumor characteristics, prognostic factors, and treatment response was extracted from publications. Results: A total of 79 studies were assigned for the present systematic review, including detection of circulating tumor cells (116 patients), circulating tumor DNA (716 patients), and circulating RNA (2887 patients). Circulating tumor cells were detected in 76% of patients. Circulating DNA was detected in 63% by targeted NGS, 66% by shallow WGS, and 79% by digital droplet PCR. Circulating RNA was detected in 37% of patients. Conclusion: Of the cTM from Ewing's sarcoma and rhabdomyosarcoma ctDNA proved to be the best target for clinical application including diagnosis, tumor characterization, prognosis, and monitoring of disease progression and treatment response. For osteosarcoma the most promising targets are copy number alterations or patient specific micro RNAs, however, further investigations are needed to obtain consensus on clinical utility.
AB - Background: Detection of circulating tumor-derived material (cTM) in the peripheral blood (PB) of cancer patients has been shown to be useful in early diagnosis, prediction of prognosis, and disease monitoring. However, it has not yet been thoroughly evaluated for pediatric sarcoma patients. Methods: We searched the PubMed and EMBASE databases for studies reporting the detection of circulating tumor cells, circulating tumor DNA, and circulating RNA in PB of pediatric sarcoma patients. Data on performance in identifying cTM and its applicability in diagnosis, and evaluation of tumor characteristics, prognostic factors, and treatment response was extracted from publications. Results: A total of 79 studies were assigned for the present systematic review, including detection of circulating tumor cells (116 patients), circulating tumor DNA (716 patients), and circulating RNA (2887 patients). Circulating tumor cells were detected in 76% of patients. Circulating DNA was detected in 63% by targeted NGS, 66% by shallow WGS, and 79% by digital droplet PCR. Circulating RNA was detected in 37% of patients. Conclusion: Of the cTM from Ewing's sarcoma and rhabdomyosarcoma ctDNA proved to be the best target for clinical application including diagnosis, tumor characterization, prognosis, and monitoring of disease progression and treatment response. For osteosarcoma the most promising targets are copy number alterations or patient specific micro RNAs, however, further investigations are needed to obtain consensus on clinical utility.
KW - CTC
KW - ctDNA
KW - ctRNA
KW - Ewing's sarcoma
KW - Osteosarcoma
KW - Rhabdomyosarcoma
U2 - 10.1016/j.tranon.2023.101690
DO - 10.1016/j.tranon.2023.101690
M3 - Journal article
C2 - 37201250
AN - SCOPUS:85159410974
VL - 34
JO - Translational Oncology
JF - Translational Oncology
SN - 1944-7124
M1 - 101690
ER -
ID: 356562056