Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.
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Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action. / Hansen, J E; Witzke, N M; Nielsen, C; Mathiesen, Lars Reinhardt; Teglbjaerg, L S; Nielsen, C M; Nielsen, Jens Ole.
In: Antiviral Research, Vol. 14, No. 3, 1990, p. 149-159.Research output: Contribution to journal › Journal article › Research
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T1 - Derivatives of amphotericin inhibit infection with human immunodeficiency virus in vitro by different modes of action.
AU - Hansen, J E
AU - Witzke, N M
AU - Nielsen, C
AU - Mathiesen, Lars Reinhardt
AU - Teglbjaerg, L S
AU - Nielsen, C M
AU - Nielsen, Jens Ole
PY - 1990
Y1 - 1990
N2 - Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.
AB - Three water-soluble derivatives of amphotericin B were tested for inhibition of HIV infection in vitro. The compounds amphotericin B methyl ester (AME) and N-(N'-(2-(4'-methylmorpholinio)ethyl)N"-cyclohexyl guanyl) amphotericin B methyl ester (MCG) inhibited HIV infection by 50% at 1 microgram/ml; N-(N'-(3-dimethylaminopropyl)N"-ethyl guanyl) amphotericin B (DAPEG) did so at 5-11 micrograms/ml. While the virus-inhibitory effect of AME was due to an interaction with target lymphocytes, the effect of MCG was due to a direct anti-viral action. AME increased the potential of infected cells to fuse with uninfected cells, but MCG had no significant effect on cell fusion. All compounds had a lower cellular toxicity than amphotericin B and were not toxic at concentrations below 20 micrograms/ml.
M3 - Journal article
VL - 14
SP - 149
EP - 159
JO - Antiviral Research
JF - Antiviral Research
SN - 0166-3542
IS - 3
ER -
ID: 34125891