Dependence of lipid membrane phase transition temperature on the mismatch of protein and lipid hydrophobic thickness
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Dependence of lipid membrane phase transition temperature on the mismatch of protein and lipid hydrophobic thickness. / Sperotto, M. M.; Mouritsen, O. G.
In: European Biophysics Journal, Vol. 16, No. 1, 1988, p. 1-10.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dependence of lipid membrane phase transition temperature on the mismatch of protein and lipid hydrophobic thickness
AU - Sperotto, M. M.
AU - Mouritsen, O. G.
PY - 1988
Y1 - 1988
N2 - A two-component solution theory is studied which incorporates hydrophobic matching as a major contribution to the lipid-protein interactions in biological membranes. A special geometrical constraint has been discovered which has important implications for the quantitative interpretation of physical effects to lipid-protein interactions. The theory has an advantage over conventional Landau-type phenomenological descriptions in that it accounts for phase separation. A certain class of experimental systems, photosynthetic reaction centre and antenna proteins reconstituted into synthetic lipid membranes of different hydrophobic thicknesses, are considered with a view to determining the parameters of the theory. The theoretical predictions are found to be in good agreement with experimental measurements of shifts in the phase transition temperature.
AB - A two-component solution theory is studied which incorporates hydrophobic matching as a major contribution to the lipid-protein interactions in biological membranes. A special geometrical constraint has been discovered which has important implications for the quantitative interpretation of physical effects to lipid-protein interactions. The theory has an advantage over conventional Landau-type phenomenological descriptions in that it accounts for phase separation. A certain class of experimental systems, photosynthetic reaction centre and antenna proteins reconstituted into synthetic lipid membranes of different hydrophobic thicknesses, are considered with a view to determining the parameters of the theory. The theoretical predictions are found to be in good agreement with experimental measurements of shifts in the phase transition temperature.
KW - hydrophobic thickness
KW - lipid membrane
KW - lipid-protein interactions
KW - membrane elasticity
KW - phase diagram
KW - solution theory
U2 - 10.1007/BF00255320
DO - 10.1007/BF00255320
M3 - Journal article
AN - SCOPUS:0001768252
VL - 16
SP - 1
EP - 10
JO - European Biophysics Journal
JF - European Biophysics Journal
SN - 0175-7571
IS - 1
ER -
ID: 238390765