Demonstration of pepsinogen C in human pancreatic islets
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Demonstration of pepsinogen C in human pancreatic islets. / Poulsen, Steen Seier.
In: Gut, Vol. 28, No. 10, 10.1987, p. 1208-14.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Demonstration of pepsinogen C in human pancreatic islets
AU - Poulsen, Steen Seier
PY - 1987/10
Y1 - 1987/10
N2 - Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.
AB - Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.
KW - Electrophoresis, Agar Gel
KW - Electrophoresis, Polyacrylamide Gel
KW - Gastric Mucosa
KW - Humans
KW - Immunoenzyme Techniques
KW - Islets of Langerhans
KW - Isoelectric Focusing
KW - Pepsinogens
M3 - Journal article
C2 - 3315877
VL - 28
SP - 1208
EP - 1214
JO - Gut
JF - Gut
SN - 0017-5749
IS - 10
ER -
ID: 47488581