Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas. / Dezso, Katalin; Halász, Judit; Bisgaard, Hanne Cathrine; Paku, Sándor; Turányi, Eszter; Schaff, Zsuzsa; Nagy, Peter.

In: Virchows Archiv, Vol. 452, No. 4, 2008, p. 443-448.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dezso, K, Halász, J, Bisgaard, HC, Paku, S, Turányi, E, Schaff, Z & Nagy, P 2008, 'Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas', Virchows Archiv, vol. 452, no. 4, pp. 443-448. https://doi.org/10.1007/s00428-007-0571-8

APA

Dezso, K., Halász, J., Bisgaard, H. C., Paku, S., Turányi, E., Schaff, Z., & Nagy, P. (2008). Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas. Virchows Archiv, 452(4), 443-448. https://doi.org/10.1007/s00428-007-0571-8

Vancouver

Dezso K, Halász J, Bisgaard HC, Paku S, Turányi E, Schaff Z et al. Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas. Virchows Archiv. 2008;452(4):443-448. https://doi.org/10.1007/s00428-007-0571-8

Author

Dezso, Katalin ; Halász, Judit ; Bisgaard, Hanne Cathrine ; Paku, Sándor ; Turányi, Eszter ; Schaff, Zsuzsa ; Nagy, Peter. / Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas. In: Virchows Archiv. 2008 ; Vol. 452, No. 4. pp. 443-448.

Bibtex

@article{daaf7180dcc211dd9473000ea68e967b,
title = "Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas",
abstract = "Delta-like protein (DLK) is a membrane protein with mostly unknown function. It is expressed by several embryonic tissues among others by the hepatoblasts of rodent and human fetal livers. We have investigated in the present study if this protein is expressed in human hepatoblastomas. The presence of DLK has been studied by standard immunohistochemistry in 31 hepatoblastomas and in several differential diagnostically related tumours: hepatocellular carcinomas and in undifferentiated childhood neoplasms. All the hepatoblastomas were positive for DLK; the surrounding liver tissue remained negative. The reaction was present in the epithelial component of the tumours. The staining pattern was mostly membranous, occasionally cytoplasmic. The other studied tumours were negative for DLK, except one hepatocellular carcinoma and the differentiating cells of two ganglioneuroblastomas. Therefore, DLK seems to be a highly sensitive and specific marker for hepatoblastomas.",
keywords = "Adolescent, Aged, Carcinoma, Hepatocellular, Child, Child, Preschool, Female, Hepatoblastoma, Humans, Infant, Intercellular Signaling Peptides and Proteins, Keratin-19, Liver, Liver Neoplasms, Male, Membrane Proteins, Middle Aged, Sensitivity and Specificity, Tumor Markers, Biological, alpha-Fetoproteins",
author = "Katalin Dezso and Judit Hal{\'a}sz and Bisgaard, {Hanne Cathrine} and S{\'a}ndor Paku and Eszter Tur{\'a}nyi and Zsuzsa Schaff and Peter Nagy",
year = "2008",
doi = "10.1007/s00428-007-0571-8",
language = "English",
volume = "452",
pages = "443--448",
journal = "Virchows Archiv",
issn = "0945-6317",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Delta-like protein (DLK) is a novel immunohistochemical marker for human hepatoblastomas

AU - Dezso, Katalin

AU - Halász, Judit

AU - Bisgaard, Hanne Cathrine

AU - Paku, Sándor

AU - Turányi, Eszter

AU - Schaff, Zsuzsa

AU - Nagy, Peter

PY - 2008

Y1 - 2008

N2 - Delta-like protein (DLK) is a membrane protein with mostly unknown function. It is expressed by several embryonic tissues among others by the hepatoblasts of rodent and human fetal livers. We have investigated in the present study if this protein is expressed in human hepatoblastomas. The presence of DLK has been studied by standard immunohistochemistry in 31 hepatoblastomas and in several differential diagnostically related tumours: hepatocellular carcinomas and in undifferentiated childhood neoplasms. All the hepatoblastomas were positive for DLK; the surrounding liver tissue remained negative. The reaction was present in the epithelial component of the tumours. The staining pattern was mostly membranous, occasionally cytoplasmic. The other studied tumours were negative for DLK, except one hepatocellular carcinoma and the differentiating cells of two ganglioneuroblastomas. Therefore, DLK seems to be a highly sensitive and specific marker for hepatoblastomas.

AB - Delta-like protein (DLK) is a membrane protein with mostly unknown function. It is expressed by several embryonic tissues among others by the hepatoblasts of rodent and human fetal livers. We have investigated in the present study if this protein is expressed in human hepatoblastomas. The presence of DLK has been studied by standard immunohistochemistry in 31 hepatoblastomas and in several differential diagnostically related tumours: hepatocellular carcinomas and in undifferentiated childhood neoplasms. All the hepatoblastomas were positive for DLK; the surrounding liver tissue remained negative. The reaction was present in the epithelial component of the tumours. The staining pattern was mostly membranous, occasionally cytoplasmic. The other studied tumours were negative for DLK, except one hepatocellular carcinoma and the differentiating cells of two ganglioneuroblastomas. Therefore, DLK seems to be a highly sensitive and specific marker for hepatoblastomas.

KW - Adolescent

KW - Aged

KW - Carcinoma, Hepatocellular

KW - Child

KW - Child, Preschool

KW - Female

KW - Hepatoblastoma

KW - Humans

KW - Infant

KW - Intercellular Signaling Peptides and Proteins

KW - Keratin-19

KW - Liver

KW - Liver Neoplasms

KW - Male

KW - Membrane Proteins

KW - Middle Aged

KW - Sensitivity and Specificity

KW - Tumor Markers, Biological

KW - alpha-Fetoproteins

U2 - 10.1007/s00428-007-0571-8

DO - 10.1007/s00428-007-0571-8

M3 - Journal article

C2 - 18236070

VL - 452

SP - 443

EP - 448

JO - Virchows Archiv

JF - Virchows Archiv

SN - 0945-6317

IS - 4

ER -

ID: 9565045