TY - JOUR

T1 - Current applications of high-resolution mass spectrometry for the analysis of new psychoactive substances

T2 - a critical review

AU - Pasin, Daniel

AU - Cawley, Adam

AU - Bidny, Sergei

AU - Fu, Shanlin

PY - 2017/10/1

Y1 - 2017/10/1

N2 - The proliferation of new psychoactive substances (NPS) in recent years has resulted in the development of numerous analytical methods for the detection and identification of known and unknown NPS derivatives. High-resolution mass spectrometry (HRMS) has been identified as the method of choice for broad screening of NPS in a wide range of analytical contexts because of its ability to measure accurate masses using data-independent acquisition (DIA) techniques. Additionally, it has shown promise for non-targeted screening strategies that have been developed in order to detect and identify novel analogues without the need for certified reference materials (CRMs) or comprehensive mass spectral libraries. This paper reviews the applications of HRMS for the analysis of NPS in forensic drug chemistry and analytical toxicology. It provides an overview of the sample preparation procedures in addition to data acquisition, instrumental analysis, and data processing techniques. Furthermore, it gives an overview of the current state of non-targeted screening strategies with discussion on future directions and perspectives of this technique. [Figure not available: see fulltext.].

AB - The proliferation of new psychoactive substances (NPS) in recent years has resulted in the development of numerous analytical methods for the detection and identification of known and unknown NPS derivatives. High-resolution mass spectrometry (HRMS) has been identified as the method of choice for broad screening of NPS in a wide range of analytical contexts because of its ability to measure accurate masses using data-independent acquisition (DIA) techniques. Additionally, it has shown promise for non-targeted screening strategies that have been developed in order to detect and identify novel analogues without the need for certified reference materials (CRMs) or comprehensive mass spectral libraries. This paper reviews the applications of HRMS for the analysis of NPS in forensic drug chemistry and analytical toxicology. It provides an overview of the sample preparation procedures in addition to data acquisition, instrumental analysis, and data processing techniques. Furthermore, it gives an overview of the current state of non-targeted screening strategies with discussion on future directions and perspectives of this technique. [Figure not available: see fulltext.].

KW - High-resolution mass spectrometry

KW - New psychoactive substances

KW - Non-targeted screening

UR - http://www.scopus.com/inward/record.url?scp=85021137873&partnerID=8YFLogxK

U2 - 10.1007/s00216-017-0441-4

DO - 10.1007/s00216-017-0441-4

M3 - Review

C2 - 28634759

AN - SCOPUS:85021137873

VL - 409

SP - 5821

EP - 5836

JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

SN - 1618-2642

IS - 25

ER -