Corticomuscular coherence in the acute and subacute phase after stroke
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Corticomuscular coherence in the acute and subacute phase after stroke. / Larsen, Lisbeth Hoejkjaer; Zibrandtsen, Ivan Chrilles; Wienecke, Troels; Kjaer, Troels Wesenberg; Christensen, Mark Schram; Nielsen, Jens Bo; Langberg, Henning.
In: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Vol. 128, No. 11, 11.2017, p. 2217-2226.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Corticomuscular coherence in the acute and subacute phase after stroke
AU - Larsen, Lisbeth Hoejkjaer
AU - Zibrandtsen, Ivan Chrilles
AU - Wienecke, Troels
AU - Kjaer, Troels Wesenberg
AU - Christensen, Mark Schram
AU - Nielsen, Jens Bo
AU - Langberg, Henning
N1 - Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
PY - 2017/11
Y1 - 2017/11
N2 - OBJECTIVE: Stroke is one of the leading causes of physical disability due to damage of the motor cortex or the corticospinal tract. In the present study we set out to investigate the role of adaptations in the corticospinal pathway for motor recovery during the subacute phase after stroke.METHODS: We examined 19 patients with clinically diagnosed stroke and 18 controls. The patients had unilateral mild to moderate weakness of the hand. Each patient attended two sessions at approximately 3days (acute) and 38days post stroke (subacute). Task-related changes in the communication between motor cortex and muscles were evaluated from coupling in the frequency domain between EEG and EMG during movement of the paretic hand.RESULTS: Corticomuscular coherence (CMC) and intermuscular coherence (IMC) were reduced in patients as compared to controls. Paretic hand motor performance improved within 4-6weeks after stroke, but no change was observed in CMC or IMC.CONCLUSIONS: CMC and IMC were reduced in patients in the early phase after stroke. However, changes in coherence do not appear to be an efficient marker for early recovery of hand function following stroke.SIGNIFICANCE: This is the first study to demonstrate sustained reduced coherence in acute and subacute stroke.
AB - OBJECTIVE: Stroke is one of the leading causes of physical disability due to damage of the motor cortex or the corticospinal tract. In the present study we set out to investigate the role of adaptations in the corticospinal pathway for motor recovery during the subacute phase after stroke.METHODS: We examined 19 patients with clinically diagnosed stroke and 18 controls. The patients had unilateral mild to moderate weakness of the hand. Each patient attended two sessions at approximately 3days (acute) and 38days post stroke (subacute). Task-related changes in the communication between motor cortex and muscles were evaluated from coupling in the frequency domain between EEG and EMG during movement of the paretic hand.RESULTS: Corticomuscular coherence (CMC) and intermuscular coherence (IMC) were reduced in patients as compared to controls. Paretic hand motor performance improved within 4-6weeks after stroke, but no change was observed in CMC or IMC.CONCLUSIONS: CMC and IMC were reduced in patients in the early phase after stroke. However, changes in coherence do not appear to be an efficient marker for early recovery of hand function following stroke.SIGNIFICANCE: This is the first study to demonstrate sustained reduced coherence in acute and subacute stroke.
U2 - 10.1016/j.clinph.2017.08.033
DO - 10.1016/j.clinph.2017.08.033
M3 - Journal article
C2 - 28987993
VL - 128
SP - 2217
EP - 2226
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 11
ER -
ID: 184802855