Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies
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Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies. / Petersen, Peter C.; Buzsáki, György.
In: Neuron, Vol. 107, No. 4, 2020, p. 731-744.e3.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cooling of Medial Septum Reveals Theta Phase Lag Coordination of Hippocampal Cell Assemblies
AU - Petersen, Peter C.
AU - Buzsáki, György
N1 - Copyright © 2020 Elsevier Inc. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Hippocampal theta oscillations coordinate neuronal firing to support memory and spatial navigation. The medial septum (MS) is critical in theta generation by two possible mechanisms: either a unitary "pacemaker" timing signal is imposed on the hippocampal system, or it may assist in organizing target subcircuits within the phase space of theta oscillations. We used temperature manipulation of the MS to test these models. Cooling of the MS reduced both theta frequency and power and was associated with an enhanced incidence of errors in a spatial navigation task, but it did not affect spatial correlates of neurons. MS cooling decreased theta frequency oscillations of place cells and reduced distance-time compression but preserved distance-phase compression of place field sequences within the theta cycle. Thus, the septum is critical for sustaining precise theta phase coordination of cell assemblies in the hippocampal system, a mechanism needed for spatial memory.
AB - Hippocampal theta oscillations coordinate neuronal firing to support memory and spatial navigation. The medial septum (MS) is critical in theta generation by two possible mechanisms: either a unitary "pacemaker" timing signal is imposed on the hippocampal system, or it may assist in organizing target subcircuits within the phase space of theta oscillations. We used temperature manipulation of the MS to test these models. Cooling of the MS reduced both theta frequency and power and was associated with an enhanced incidence of errors in a spatial navigation task, but it did not affect spatial correlates of neurons. MS cooling decreased theta frequency oscillations of place cells and reduced distance-time compression but preserved distance-phase compression of place field sequences within the theta cycle. Thus, the septum is critical for sustaining precise theta phase coordination of cell assemblies in the hippocampal system, a mechanism needed for spatial memory.
KW - Action Potentials/physiology
KW - Animals
KW - Cold Temperature
KW - Hippocampus/physiology
KW - Male
KW - Models, Neurological
KW - Neurons/physiology
KW - Place Cells/physiology
KW - Rats
KW - Rats, Long-Evans
KW - Septal Nuclei/physiology
KW - Spatial Memory/physiology
KW - Theta Rhythm/physiology
U2 - 10.1016/j.neuron.2020.05.023
DO - 10.1016/j.neuron.2020.05.023
M3 - Journal article
C2 - 32526196
VL - 107
SP - 731-744.e3
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 4
ER -
ID: 339356023