TY - JOUR

T1 - Contrast-induced nephropathy: The wheel has turned 360 degrees

AU - Thomsen, H.S.

AU - Morcos, S.K.

AU - Barrett, B.J.

AU - Thomsen, Henrik S.

N1 - Times Cited: 0ReviewEnglishThomsen, H. SUniv Copenhagen, Herlev Hosp, Dept Diagnost Radiol 54E2, Herlev Ringvej 75, DK-2730 Herlev, DenmarkCited References Count: 106316VRTAYLOR & FRANCIS LTD4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDABINGDON

PY - 2008

Y1 - 2008

N2 - Contrast-induced nephropathy (CIN) has been a hot topic during the last 5 years due its association with increased morbidity and mortality. CIN is an important complication, particularly in patients with advanced chronic kidney disease (CKD) associated with diabetes mellitus. Methods to diminish the incidence of CIN have been highly contentious. They include choice of contrast, pharmacologic manipulation, and volume expansion. The pathophysiology of this complication remains uncertain, but reduction in renal blood flow and direct toxicity of tubular cells has been implicated. More than 900 publications under the heading CIN have been published during the last 5 years. Fewer than 5% of these publications are randomized prospective controlled studies. In spite of the large number of reports on CIN, very little has been changed. The use of the smallest possible dose of low- or iso-osmolar contrast media, volume expansion, stopping nephrotoxic drugs, and avoiding repeat contrast injections within 48 hours remain the most effective approach to reduce the risk of CIN Udgivelsesdato: 2008

AB - Contrast-induced nephropathy (CIN) has been a hot topic during the last 5 years due its association with increased morbidity and mortality. CIN is an important complication, particularly in patients with advanced chronic kidney disease (CKD) associated with diabetes mellitus. Methods to diminish the incidence of CIN have been highly contentious. They include choice of contrast, pharmacologic manipulation, and volume expansion. The pathophysiology of this complication remains uncertain, but reduction in renal blood flow and direct toxicity of tubular cells has been implicated. More than 900 publications under the heading CIN have been published during the last 5 years. Fewer than 5% of these publications are randomized prospective controlled studies. In spite of the large number of reports on CIN, very little has been changed. The use of the smallest possible dose of low- or iso-osmolar contrast media, volume expansion, stopping nephrotoxic drugs, and avoiding repeat contrast injections within 48 hours remain the most effective approach to reduce the risk of CIN Udgivelsesdato: 2008

M3 - Journal article

VL - 49

SP - 646

EP - 657

JO - Acta Radiologica - Series Diagnosis

JF - Acta Radiologica - Series Diagnosis

SN - 0365-5954

IS - 6

ER -