TY - JOUR

T1 - Contending with transcriptional arrest during RNAPII transcript elongation

AU - Svejstrup, Jesper Q.

N1 - Funding Information: Research in the Svejstrup laboratory is supported by a generous in-house grant from Cancer Research UK, and by funding provided by the EU and AICR.

PY - 2007/4

Y1 - 2007/4

N2 - Studies of RNA polymerase II (RNAPII) transcript elongation have revealed an extremely complex biochemical process. Obstacles to transcription, such as nucleosomes and DNA damage, must be overcome constantly, requiring the involvement of numerous accessory factors with diverse functions. Together, these factors ensure that transcript elongation is, overall, a highly efficient reaction. The understanding of the basic biochemical principles and factors underlying transcript elongation by RNAPII has greatly improved over the past few years. In particular, studies of RNAPII ubiquitylation and degradation have provided new insight into how cells handle obstacle-induced transcriptional arrest.

AB - Studies of RNA polymerase II (RNAPII) transcript elongation have revealed an extremely complex biochemical process. Obstacles to transcription, such as nucleosomes and DNA damage, must be overcome constantly, requiring the involvement of numerous accessory factors with diverse functions. Together, these factors ensure that transcript elongation is, overall, a highly efficient reaction. The understanding of the basic biochemical principles and factors underlying transcript elongation by RNAPII has greatly improved over the past few years. In particular, studies of RNAPII ubiquitylation and degradation have provided new insight into how cells handle obstacle-induced transcriptional arrest.

U2 - 10.1016/j.tibs.2007.02.005

DO - 10.1016/j.tibs.2007.02.005

M3 - Review

C2 - 17349792

AN - SCOPUS:34247096165

VL - 32

SP - 165

EP - 171

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 4

ER -