Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets
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Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets. / Due, Anette Pia; Larsen, Thomas Meinert; Hermansen, Kjeld; Stender, Steen; Holst, Jens Juul; Toubro, Søren; Martinussen, Torben; Astrup, Arne.
In: American Journal of Clinical Nutrition, Vol. 87, No. 4, 2008, p. 855-862.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets
AU - Due, Anette Pia
AU - Larsen, Thomas Meinert
AU - Hermansen, Kjeld
AU - Stender, Steen
AU - Holst, Jens Juul
AU - Toubro, Søren
AU - Martinussen, Torben
AU - Astrup, Arne
PY - 2008
Y1 - 2008
N2 - Background: The effect of dietary fat and carbohydrate on glucose metabolism has been debated for decades. Objective: The objective was to compare the effect of 3 ad libitum diets, different in type and amount of fat and carbohydrate, on insulin resistance and glucose tolerance subsequent to weight loss. Design: Forty-six nondiabetic, obese [mean (±SEM) body mass index (in kg/m2): 31.2 ± 0.3] men (n = 20) and premenopausal women (n = 26) aged 28.0 ± 0.7 y were randomly assigned to 1 of 3 diets after ≥8% weight loss: 1) MUFA diet (n = 16): moderate in fat (35-45% of energy) and high in monounsaturated fatty acids (>20% of energy); 2) LF diet (n = 18): low-fat diet (20-30% of energy), and 3) control diet (n = 12): 35% of energy as fat (>15% of energy as saturated fatty acids). Protein accounted for 15% of energy in all 3 diets. A 2-h oral-glucose-tolerance test (OGTT) was performed before and after the 6-mo dietary intervention. All foods were provided by a purpose-built supermarket. Results: After 6 mo, the MUFA diet reduced fasting glucose (-3.0%), insulin (-9.4%), and the homeostasis model assessment of insulin resistance score (-12.1%). Compared with the MUFA diet, the control diet increased these variables [1.4% (P = 0.014), 21.2% (P=0.030), and 22.8% (P=0.015), respectively], as did the LF diet [1.4% (P = 0.090), 13.1% (P = 0.078), and 15.5% (P = 0.095), respectively]. No significant group differences were detected in glucose or insulin concentrations during the OGTT, in the Matsudas index, in body weight, or in body composition. Conclusion: A diet high in monounsaturated fat has a more favorable effect on glucose homeostasis than does the typical Western diet in the short term and may also be more beneficial than the official recommended low-fat diet during a period of weight regain subsequent to weight loss. This trial was registered at clinicaltrials.gov as NCT00274729.
AB - Background: The effect of dietary fat and carbohydrate on glucose metabolism has been debated for decades. Objective: The objective was to compare the effect of 3 ad libitum diets, different in type and amount of fat and carbohydrate, on insulin resistance and glucose tolerance subsequent to weight loss. Design: Forty-six nondiabetic, obese [mean (±SEM) body mass index (in kg/m2): 31.2 ± 0.3] men (n = 20) and premenopausal women (n = 26) aged 28.0 ± 0.7 y were randomly assigned to 1 of 3 diets after ≥8% weight loss: 1) MUFA diet (n = 16): moderate in fat (35-45% of energy) and high in monounsaturated fatty acids (>20% of energy); 2) LF diet (n = 18): low-fat diet (20-30% of energy), and 3) control diet (n = 12): 35% of energy as fat (>15% of energy as saturated fatty acids). Protein accounted for 15% of energy in all 3 diets. A 2-h oral-glucose-tolerance test (OGTT) was performed before and after the 6-mo dietary intervention. All foods were provided by a purpose-built supermarket. Results: After 6 mo, the MUFA diet reduced fasting glucose (-3.0%), insulin (-9.4%), and the homeostasis model assessment of insulin resistance score (-12.1%). Compared with the MUFA diet, the control diet increased these variables [1.4% (P = 0.014), 21.2% (P=0.030), and 22.8% (P=0.015), respectively], as did the LF diet [1.4% (P = 0.090), 13.1% (P = 0.078), and 15.5% (P = 0.095), respectively]. No significant group differences were detected in glucose or insulin concentrations during the OGTT, in the Matsudas index, in body weight, or in body composition. Conclusion: A diet high in monounsaturated fat has a more favorable effect on glucose homeostasis than does the typical Western diet in the short term and may also be more beneficial than the official recommended low-fat diet during a period of weight regain subsequent to weight loss. This trial was registered at clinicaltrials.gov as NCT00274729.
UR - http://www.scopus.com/inward/record.url?scp=42249098883&partnerID=8YFLogxK
M3 - Journal article
C2 - 18400707
AN - SCOPUS:42249098883
VL - 87
SP - 855
EP - 862
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -
ID: 210054756