Cognitive impairment is common in patients with severe astma that are commenced on a biological treatment
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Cognitive impairment is common in patients with severe astma that are commenced on a biological treatment. / Bernhoff, C.; Jespersen, A. E.; Dyhre-Petersen, N.; Klein, D. K.; Miskowiak, K. W.; Porsbjerg, C. M.
In: European Respiratory Journal, Vol. 60, 4644, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cognitive impairment is common in patients with severe astma that are commenced on a biological treatment
AU - Bernhoff, C.
AU - Jespersen, A. E.
AU - Dyhre-Petersen, N.
AU - Klein, D. K.
AU - Miskowiak, K. W.
AU - Porsbjerg, C. M.
PY - 2022
Y1 - 2022
N2 - Introduction: Patients with severe asthma often complain of fatigue and difficulty concentrating, which affects their work and family life. Asthma is known to be associated with cognitive impairment, but the level and severity has not been described in severe eosinophilic asthma.Aims: To investigate the frequency, pattern, and severity of cognitive impairment in patients with poorly controlled severe eosinophilic asthma.Methods: Cognitive impairment was assessed in the 3TR Asthma Biologics Cohort study, in patients with severe eosinophilic asthma before commencing a biological treatment. Objective cognitive functions were assessed with a performance-based test battery consisting of screening for cognitive impairment with the Psychiatry Danish Version and the trail Making Test-Part B: Verbal learning and memory, working memory, verbal fluency, processing speed and executive function. Subjective cognitive functions were assessed with the Cognitive Failures Questionnaire.Results: In the 18 patients assessed, 50% to 56% had clinically significant cognitive impairment, depending on the applied cut-off for clinical relevance of cognitive impairment, when compared with their expected performance based on their individual age, education level and gender. Analyses of the pattern and severity of the cognitive impairment revealed that verbal learning and memory function was most severely affected (p<0.04)Conclusions: Among patients with severe eosinophilic asthma, a large proportion of the patients displayed cognitive impairment with verbal learning and memory being most affected. The effect of biologics on cognitive impairment will be evaluated in the 3TR-ABC study.
AB - Introduction: Patients with severe asthma often complain of fatigue and difficulty concentrating, which affects their work and family life. Asthma is known to be associated with cognitive impairment, but the level and severity has not been described in severe eosinophilic asthma.Aims: To investigate the frequency, pattern, and severity of cognitive impairment in patients with poorly controlled severe eosinophilic asthma.Methods: Cognitive impairment was assessed in the 3TR Asthma Biologics Cohort study, in patients with severe eosinophilic asthma before commencing a biological treatment. Objective cognitive functions were assessed with a performance-based test battery consisting of screening for cognitive impairment with the Psychiatry Danish Version and the trail Making Test-Part B: Verbal learning and memory, working memory, verbal fluency, processing speed and executive function. Subjective cognitive functions were assessed with the Cognitive Failures Questionnaire.Results: In the 18 patients assessed, 50% to 56% had clinically significant cognitive impairment, depending on the applied cut-off for clinical relevance of cognitive impairment, when compared with their expected performance based on their individual age, education level and gender. Analyses of the pattern and severity of the cognitive impairment revealed that verbal learning and memory function was most severely affected (p<0.04)Conclusions: Among patients with severe eosinophilic asthma, a large proportion of the patients displayed cognitive impairment with verbal learning and memory being most affected. The effect of biologics on cognitive impairment will be evaluated in the 3TR-ABC study.
U2 - 10.1183/13993003.congress-2022.4644
DO - 10.1183/13993003.congress-2022.4644
M3 - Journal article
VL - 60
JO - The European respiratory journal
JF - The European respiratory journal
SN - 0903-1936
M1 - 4644
ER -
ID: 346261382