Clinical PET/MR Imaging in Dementia and Neuro-Oncology
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Clinical PET/MR Imaging in Dementia and Neuro-Oncology. / Henriksen, Otto M.; Marner, Lisbeth; Law, Ian.
In: PET Clinics, Vol. 11, No. 4, 10.2016, p. 441-52.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Clinical PET/MR Imaging in Dementia and Neuro-Oncology
AU - Henriksen, Otto M.
AU - Marner, Lisbeth
AU - Law, Ian
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2016/10
Y1 - 2016/10
N2 - The introduction of hybrid PET/MRI systems allows simultaneous multimodality image acquisition of high technical quality. This technique is well suited for the brain, and particularly in dementia and neuro-oncology. In routine use combinations of well-established MRI sequences and PET tracers provide the most optimal and clinically valuable protocols. For dementia the [18F]-fluorodeoxyglucose (FDG) has merit with a simultaneous four sequence MRI protocol of 20 min supported by supplementary statistical reading tools and quantitative measurements of the hippocampal volume. Clinical PET/MRI using [18F]-fluoro-ethyl-tyrosine (FET) also abide to the expectations of the adaptive and versatile diagnostic tool necessary in neuro-oncology covering both simple 20 min protocols for routine treatment surveillance and complicated 90 min brain and spinal cord protocols in pediatric neuro-oncology under general anesthesia. The clinical value of adding advanced MRI sequences in multiparametric imaging setting, however, is still undocumented.
AB - The introduction of hybrid PET/MRI systems allows simultaneous multimodality image acquisition of high technical quality. This technique is well suited for the brain, and particularly in dementia and neuro-oncology. In routine use combinations of well-established MRI sequences and PET tracers provide the most optimal and clinically valuable protocols. For dementia the [18F]-fluorodeoxyglucose (FDG) has merit with a simultaneous four sequence MRI protocol of 20 min supported by supplementary statistical reading tools and quantitative measurements of the hippocampal volume. Clinical PET/MRI using [18F]-fluoro-ethyl-tyrosine (FET) also abide to the expectations of the adaptive and versatile diagnostic tool necessary in neuro-oncology covering both simple 20 min protocols for routine treatment surveillance and complicated 90 min brain and spinal cord protocols in pediatric neuro-oncology under general anesthesia. The clinical value of adding advanced MRI sequences in multiparametric imaging setting, however, is still undocumented.
KW - Brain
KW - Brain Mapping
KW - Brain Neoplasms
KW - Dementia
KW - Humans
KW - Magnetic Resonance Imaging
KW - Multimodal Imaging
KW - Positron-Emission Tomography
KW - Journal Article
KW - Review
U2 - 10.1016/j.cpet.2016.05.003
DO - 10.1016/j.cpet.2016.05.003
M3 - Review
C2 - 27593248
VL - 11
SP - 441
EP - 452
JO - P E T Clinics
JF - P E T Clinics
SN - 1556-8598
IS - 4
ER -
ID: 179311788