Chronic non-cancer pain and the epidemic prescription of opioids in the Danish population: trends from 2000 to 2013
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Chronic non-cancer pain and the epidemic prescription of opioids in the Danish population : trends from 2000 to 2013. / Birke, H; Kurita, G P; Sjøgren, P; Højsted, J; Simonsen, M K; Juel, K.; Ekholm, O.
In: Acta Anaesthesiologica Scandinavica, Vol. 60, No. 5, 05.2016, p. 623-633.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Chronic non-cancer pain and the epidemic prescription of opioids in the Danish population
T2 - trends from 2000 to 2013
AU - Birke, H
AU - Kurita, G P
AU - Sjøgren, P
AU - Højsted, J
AU - Simonsen, M K
AU - Juel, K.
AU - Ekholm, O
N1 - © 2016 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
PY - 2016/5
Y1 - 2016/5
N2 - BACKGROUND: Chronic pain has serious consequences for individuals and society. In addition, opioid prescription for chronic non-cancer pain (CNCP) has become more frequent. This study aims to examine the trends regarding the prevalence of CNCP, dispensed opioids, and concurrent use of benzodiazepine (BZD)/BZD-related drugs in the Danish population.METHODS: Data from the cross-sectional national representative Danish Health and Morbidity Surveys (2000, 2005, 2010, and 2013) were combined with The Danish National Prescription Registry at an individual level. The study populations varied between 5000 and 13,000 individuals ≥16 years (response rates: 51-63%). Respondents completed a self-administered questionnaire, which included the analyzed items on identification of chronic pain (≥6 months).RESULTS: From 2000 to 2013, the prevalence of CNCP increased and subsequently the annual prevalence of opioid use from 4.1% to 5.7% among CNCP individuals. Higher CNCP prevalence was related to female gender, no cohabitation partner, short education, non-Western origin, and overweight/obesity. In addition, women with CNCP, especially >65 years, became more frequent users of opioids and used higher doses than men. Concurrent use of BZD/BZD-related drugs decreased (13%) from 2010 to 2013, still one-third of long-term opioid user were co-medicated with these drugs.CONCLUSIONS: The use of opioids has increased in Denmark, especially among elderly women. The concurrent use of BZD/BZD-related drugs has decreased from 2010 to 2013, but still one-third of long-term opioid users were co-medicated.
AB - BACKGROUND: Chronic pain has serious consequences for individuals and society. In addition, opioid prescription for chronic non-cancer pain (CNCP) has become more frequent. This study aims to examine the trends regarding the prevalence of CNCP, dispensed opioids, and concurrent use of benzodiazepine (BZD)/BZD-related drugs in the Danish population.METHODS: Data from the cross-sectional national representative Danish Health and Morbidity Surveys (2000, 2005, 2010, and 2013) were combined with The Danish National Prescription Registry at an individual level. The study populations varied between 5000 and 13,000 individuals ≥16 years (response rates: 51-63%). Respondents completed a self-administered questionnaire, which included the analyzed items on identification of chronic pain (≥6 months).RESULTS: From 2000 to 2013, the prevalence of CNCP increased and subsequently the annual prevalence of opioid use from 4.1% to 5.7% among CNCP individuals. Higher CNCP prevalence was related to female gender, no cohabitation partner, short education, non-Western origin, and overweight/obesity. In addition, women with CNCP, especially >65 years, became more frequent users of opioids and used higher doses than men. Concurrent use of BZD/BZD-related drugs decreased (13%) from 2010 to 2013, still one-third of long-term opioid user were co-medicated with these drugs.CONCLUSIONS: The use of opioids has increased in Denmark, especially among elderly women. The concurrent use of BZD/BZD-related drugs has decreased from 2010 to 2013, but still one-third of long-term opioid users were co-medicated.
KW - Adolescent
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Analgesics, Opioid
KW - Benzodiazepines
KW - Chronic Pain
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Denmark
KW - Drug Prescriptions
KW - Drug Therapy, Combination
KW - Drug Utilization
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Opioid-Related Disorders
KW - Population
KW - Sex Factors
KW - Socioeconomic Factors
KW - Surveys and Questionnaires
KW - Young Adult
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1111/aas.12700
DO - 10.1111/aas.12700
M3 - Journal article
C2 - 26861026
VL - 60
SP - 623
EP - 633
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
SN - 0001-5172
IS - 5
ER -
ID: 173591561