Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion
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Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion. / Hjerpsted, Julie Bousgaard; Dragsted, Lars Ove; Tholstrup, Tine.
In: Journal of Nutrition & Intermediary Metabolism, Vol. 3, No. 1, 2016, p. 12-17.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion
AU - Hjerpsted, Julie Bousgaard
AU - Dragsted, Lars Ove
AU - Tholstrup, Tine
N1 - CURIS 2016 NEXS 147
PY - 2016
Y1 - 2016
N2 - Purpose Cheese is a dairy product with high calcium content. It has been suggested that calcium intake may increase fecal excretion of bile acids that would cause a regeneration of bile acids from hepatic cholesterol and thereby result in a lowering of plasma cholesterol concentrations. We aimed to test this hypothesis by assessing bile acid and calcium concentrations in fecal samples from humans after intake of cheese and butter. Methods The study was a randomized, 2 × 6 weeks crossover, dietary intervention study including 23 men and women who replaced part of their habitual dietary fat intake with 13% energy from cheese or butter. Results After 6 weeks of intervention cheese resulted in higher amounts of calcium excreted in feces compared to butter. However, no difference was observed in fecal bile acid output despite lower serum total, LDL and HDL cholesterol concentrations observed with cheese intake. Conclusion We were not able to confirm the hypothesis that calcium from cheese increases the excretion of fecal bile acids. Therefore, the mechanisms responsible for the lowering of cholesterol concentrations with cheese compared to butter intake remains unresolved.
AB - Purpose Cheese is a dairy product with high calcium content. It has been suggested that calcium intake may increase fecal excretion of bile acids that would cause a regeneration of bile acids from hepatic cholesterol and thereby result in a lowering of plasma cholesterol concentrations. We aimed to test this hypothesis by assessing bile acid and calcium concentrations in fecal samples from humans after intake of cheese and butter. Methods The study was a randomized, 2 × 6 weeks crossover, dietary intervention study including 23 men and women who replaced part of their habitual dietary fat intake with 13% energy from cheese or butter. Results After 6 weeks of intervention cheese resulted in higher amounts of calcium excreted in feces compared to butter. However, no difference was observed in fecal bile acid output despite lower serum total, LDL and HDL cholesterol concentrations observed with cheese intake. Conclusion We were not able to confirm the hypothesis that calcium from cheese increases the excretion of fecal bile acids. Therefore, the mechanisms responsible for the lowering of cholesterol concentrations with cheese compared to butter intake remains unresolved.
KW - Bile acid
KW - Blood lipids
KW - Cardiovascular
KW - Cholesterol
KW - Dairy
U2 - 10.1016/j.jnim.2015.11.002
DO - 10.1016/j.jnim.2015.11.002
M3 - Journal article
AN - SCOPUS:84959419752
VL - 3
SP - 12
EP - 17
JO - Journal of Nutrition & Intermediary Metabolism
JF - Journal of Nutrition & Intermediary Metabolism
SN - 2352-3859
IS - 1
ER -
ID: 162341481