Characterization of naïve, memory and effector T cells in progressive multiple sclerosis
Research output: Contribution to journal › Journal article › Research › peer-review
We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.
Original language | English |
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Journal | Journal of Neuroimmunology |
Volume | 310 |
Pages (from-to) | 17-25 |
Number of pages | 9 |
ISSN | 0165-5728 |
DOIs | |
Publication status | Published - 2017 |
- CD26, CD49, Memory, Natalizumab, Progressive MS, T cells
Research areas
ID: 196908358