Characteristics of Patients With Psoriasis Treated With Various Biologics – A Danish Cohort Study
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Characteristics of Patients With Psoriasis Treated With Various Biologics – A Danish Cohort Study. / Schwarz, Christopher Willy; Skov, Lone; Egeberg, Alexander; Passey, Alun; Lee, Jennifer; Gorecki, Patricia; Loft, Nikolai.
In: Journal of Psoriasis and Psoriatic Arthritis, Vol. 9, No. 2, 2024, p. 51-60.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Characteristics of Patients With Psoriasis Treated With Various Biologics – A Danish Cohort Study
AU - Schwarz, Christopher Willy
AU - Skov, Lone
AU - Egeberg, Alexander
AU - Passey, Alun
AU - Lee, Jennifer
AU - Gorecki, Patricia
AU - Loft, Nikolai
N1 - Publisher Copyright: © The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - Background: Psoriasis is associated with several comorbidities and patients with psoriasis are more often obese than individuals without psoriasis. The excess disease burden is important to consider in choice of and response to treatment at the individual level. Objective: To investigate whether patient characteristics differ across biologics for patients initiating biologic therapy and for patients still on biologic therapy after 1 year. Also, to quantify and compare the use of topical therapy among patients still on biologic therapy after 1 year. Methods: This nationwide cohort study compared characteristics of patients prescribed adalimumab, etanercept, infliximab, secukinumab or ustekinumab for treatment of psoriasis by using data from the Danish registries. Results: In the ustekinumab group, patients were younger and fewer had psoriatic arthritis. Patients treated with secukinumab and ustekinumab were less frequently co-treated with conventional systemics and topical therapy. All other patient characteristics such as sex, smoking and comorbidities other than psoriatic arthritis were similar across the biologic cohorts. Conclusion: These results highlight the need to better understand which factors to consider when prescribing biologics to patients with psoriasis.
AB - Background: Psoriasis is associated with several comorbidities and patients with psoriasis are more often obese than individuals without psoriasis. The excess disease burden is important to consider in choice of and response to treatment at the individual level. Objective: To investigate whether patient characteristics differ across biologics for patients initiating biologic therapy and for patients still on biologic therapy after 1 year. Also, to quantify and compare the use of topical therapy among patients still on biologic therapy after 1 year. Methods: This nationwide cohort study compared characteristics of patients prescribed adalimumab, etanercept, infliximab, secukinumab or ustekinumab for treatment of psoriasis by using data from the Danish registries. Results: In the ustekinumab group, patients were younger and fewer had psoriatic arthritis. Patients treated with secukinumab and ustekinumab were less frequently co-treated with conventional systemics and topical therapy. All other patient characteristics such as sex, smoking and comorbidities other than psoriatic arthritis were similar across the biologic cohorts. Conclusion: These results highlight the need to better understand which factors to consider when prescribing biologics to patients with psoriasis.
KW - biological products
KW - comorbidity
KW - epidemiology
KW - psoriasis
KW - registries
U2 - 10.1177/24755303241234292
DO - 10.1177/24755303241234292
M3 - Journal article
AN - SCOPUS:85186183984
VL - 9
SP - 51
EP - 60
JO - Journal of Psoriasis and Psoriatic Arthritis
JF - Journal of Psoriasis and Psoriatic Arthritis
SN - 2475-5303
IS - 2
ER -
ID: 385217945