Cerebrovascular effects of the converting enzyme inhibitor captopril
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Cerebrovascular effects of the converting enzyme inhibitor captopril. / Jarden, J O; Barry, D I; Strandgaard, S; Graham, D I; Paulson, O B.
In: Journal of Hypertension, Vol. 1, No. Suppl2, 12.1983, p. 126-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cerebrovascular effects of the converting enzyme inhibitor captopril
AU - Jarden, J O
AU - Barry, D I
AU - Strandgaard, S
AU - Graham, D I
AU - Paulson, O B
PY - 1983/12
Y1 - 1983/12
N2 - The effect of captopril on cerebral blood flow (CBF) and its autoregulation was studied in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Wistar rats. CBF was measured by the intracarotid 133Xe injection method. In one study 1 and 10 mg/kg captopril respectively were given intravenously to SHR and WKY. This caused the blood pressure to fall transiently below the lower blood pressure limit of CBF autoregulation; nonetheless CBF remained normal during captopril induced hypotension. In a second study it was shown with an integral uptake method that captopril is a very poor penetrator of the blood-brain barrier. In a third study captopril was instilled intracerebroventricularly in Wistar rats without any effect on CBF or its autoregulation. Thus when given intravenously, but not intracerebroventricularly captopril caused cerebral vasodilatation during acute hypotension.
AB - The effect of captopril on cerebral blood flow (CBF) and its autoregulation was studied in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Wistar rats. CBF was measured by the intracarotid 133Xe injection method. In one study 1 and 10 mg/kg captopril respectively were given intravenously to SHR and WKY. This caused the blood pressure to fall transiently below the lower blood pressure limit of CBF autoregulation; nonetheless CBF remained normal during captopril induced hypotension. In a second study it was shown with an integral uptake method that captopril is a very poor penetrator of the blood-brain barrier. In a third study captopril was instilled intracerebroventricularly in Wistar rats without any effect on CBF or its autoregulation. Thus when given intravenously, but not intracerebroventricularly captopril caused cerebral vasodilatation during acute hypotension.
KW - Animals
KW - Blood Pressure/drug effects
KW - Blood-Brain Barrier
KW - Captopril/metabolism
KW - Cerebrovascular Circulation/drug effects
KW - Homeostasis
KW - Rats
KW - Rats, Inbred SHR
KW - Rats, Inbred Strains
KW - Rats, Inbred WKY
M3 - Journal article
C2 - 6400112
VL - 1
SP - 126
EP - 128
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - Suppl2
ER -
ID: 279584735