Cerebrospinal fluid glucose is not altered in patients with dementia
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Cerebrospinal fluid glucose is not altered in patients with dementia. / Jensen, Camilla Steen; Gleerup, Helena Sophia; Musaeus, Christian Sandøe; Hasselbalch, Steen Gregers; Høgh, Peter; Waldemar, Gunhild; Simonsen, Anja Hviid.
In: Clinical Biochemistry, Vol. 112, 2023, p. 1-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cerebrospinal fluid glucose is not altered in patients with dementia
AU - Jensen, Camilla Steen
AU - Gleerup, Helena Sophia
AU - Musaeus, Christian Sandøe
AU - Hasselbalch, Steen Gregers
AU - Høgh, Peter
AU - Waldemar, Gunhild
AU - Simonsen, Anja Hviid
N1 - Publisher Copyright: © 2022 The Authors
PY - 2023
Y1 - 2023
N2 - Background: Studies have shown that the pathological changes of many dementia disorders begin several years before clinical onset. A connection between some of these pathophysiological changes and brain hypometabolism, seen in dementia disorders, is well established. Glucose is transported from the blood into the interstitial space, and the decreased demand for glucose by the degenerating brain tissue may thereby mirror increased levels of cerebrospinal fluid (CSF) glucose. In this study, the levels of CSF and plasma glucose and the CSF/plasma glucose ratio were investigated in a large cohort from a mixed memory clinic population in order to evaluate its diagnostic potential. Method: CSF and plasma samples were taken from 446 patients (Alzheimer's Disease (AD) (n = 320), vascular dementia (VaD) (n = 64), frontotemporal dementia (FTD) (n = 27) and dementia with Lewy bodies (DLB) (n = 35)), and 130 healthy controls (HC) (healthy subjects (HS) (n = 34), non-demented HS (n = 96)). Results: No significant differences were found for CSF and plasma glucose or the CSF/plasma glucose ratio between patients with dementia disorders and HC. In addition, no significant differences were observed between the different dementia etiologies. Conclusion: CSF and plasma glucose were not useful to differentiate between HC and patients with various dementia disorders.
AB - Background: Studies have shown that the pathological changes of many dementia disorders begin several years before clinical onset. A connection between some of these pathophysiological changes and brain hypometabolism, seen in dementia disorders, is well established. Glucose is transported from the blood into the interstitial space, and the decreased demand for glucose by the degenerating brain tissue may thereby mirror increased levels of cerebrospinal fluid (CSF) glucose. In this study, the levels of CSF and plasma glucose and the CSF/plasma glucose ratio were investigated in a large cohort from a mixed memory clinic population in order to evaluate its diagnostic potential. Method: CSF and plasma samples were taken from 446 patients (Alzheimer's Disease (AD) (n = 320), vascular dementia (VaD) (n = 64), frontotemporal dementia (FTD) (n = 27) and dementia with Lewy bodies (DLB) (n = 35)), and 130 healthy controls (HC) (healthy subjects (HS) (n = 34), non-demented HS (n = 96)). Results: No significant differences were found for CSF and plasma glucose or the CSF/plasma glucose ratio between patients with dementia disorders and HC. In addition, no significant differences were observed between the different dementia etiologies. Conclusion: CSF and plasma glucose were not useful to differentiate between HC and patients with various dementia disorders.
KW - Alzheimer's disease
KW - Cerebrospinal fluid
KW - Dementia with Lewy bodies
KW - Frontotemporal dementia
KW - Glucose
KW - Plasma
KW - Vascular dementia
U2 - 10.1016/j.clinbiochem.2022.12.005
DO - 10.1016/j.clinbiochem.2022.12.005
M3 - Journal article
C2 - 36502885
AN - SCOPUS:85144506826
VL - 112
SP - 1
EP - 5
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
ER -
ID: 363060856