Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study
Research output: Contribution to journal › Journal article › Research › peer-review
Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability.
Original language | English |
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Journal | Neurological Research |
Volume | 34 |
Issue number | 1 |
Pages (from-to) | 52-8 |
Number of pages | 7 |
ISSN | 0161-6412 |
DOIs | |
Publication status | Published - Jan 2012 |
ID: 48525026