Cardiac Characteristics of the First Two Waves of COVID-19 in Denmark and the Prognostic Value of Echocardiography: The ECHOVID-19 Study
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Cardiac Characteristics of the First Two Waves of COVID-19 in Denmark and the Prognostic Value of Echocardiography : The ECHOVID-19 Study. / Christensen, Jacob; Skaarup, Kristoffer Grundtvig; Lassen, Mats Christian Højbjerg; Alhakak, Alia Sead; Sengeløv, Morten; Nielsen, Anne Bjerg; Johansen, Niklas Dyrby; Bundgaard, Henning; Hassager, Christian; Jabbari, Reza; Carlsen, Jørn; Kirk, Ole; Kristiansen, Ole Peter; Nielsen, Olav Wendelboe; Ulrik, Charlotte Suppli; Sivapalan, Pradeesh; Gislason, Gunnar; Iversen, Kasper; Jensen, Jens Ulrik Stæhr; Schou, Morten; Hviid, Anders; Krause, Tyra Grove; Biering-Sørensen, Tor; Davidovski, Filip Søskov.
In: Cardiology (Switzerland), Vol. 148, No. 1, 01.02.2023, p. 48-57.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cardiac Characteristics of the First Two Waves of COVID-19 in Denmark and the Prognostic Value of Echocardiography
T2 - The ECHOVID-19 Study
AU - Christensen, Jacob
AU - Skaarup, Kristoffer Grundtvig
AU - Lassen, Mats Christian Højbjerg
AU - Alhakak, Alia Sead
AU - Sengeløv, Morten
AU - Nielsen, Anne Bjerg
AU - Johansen, Niklas Dyrby
AU - Bundgaard, Henning
AU - Hassager, Christian
AU - Jabbari, Reza
AU - Carlsen, Jørn
AU - Kirk, Ole
AU - Kristiansen, Ole Peter
AU - Nielsen, Olav Wendelboe
AU - Ulrik, Charlotte Suppli
AU - Sivapalan, Pradeesh
AU - Gislason, Gunnar
AU - Iversen, Kasper
AU - Jensen, Jens Ulrik Stæhr
AU - Schou, Morten
AU - Hviid, Anders
AU - Krause, Tyra Grove
AU - Biering-Sørensen, Tor
AU - Davidovski, Filip Søskov
N1 - Publisher Copyright: © 2022 Authors. All rights reserved.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Introduction: COVID-19 has spread globally in waves, and Danish treatment guidelines have been updated following the first wave. We sought to investigate whether the prognostic values of echocardiographic parameters changed with updates in treatment guidelines and the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, 20E (EU1) and alpha (B.1.1.7), and further to compare cardiac parameters between patients from the first and second wave. Methods: A total of 305 patients hospitalized with COVID-19 were prospectively included, 215 and 90 during the first and second wave, respectively. Treatment in the study was defined as treatment with remdesivir, dexamethasone, or both. Patients were assumed to be infected with the dominant SARS-CoV-2 variant at the time of their hospitalization. Results: Mean age for the first versus second wave was 68.7 ± 13.6 versus 69.7 ± 15.8 years, and 55% versus 62% were males. Left ventricular (LV) systolic and diastolic function was worse in patients hospitalized during the second wave (LV ejection fraction [LVEF] for first vs. second wave = 58.5 ± 8.1% vs. 52.4 ± 10.6%, p < 0.001; and global longitudinal strain [GLS] = 16.4 ± 4.3% vs. 14.2 ± 4.3%, p < 0.001). In univariable Cox regressions, reduced LVEF (hazard ratio [HR] = 1.07 per 1% decrease, p = 0.002), GLS (HR = 1.21 per 1% decrease, p < 0.001), and tricuspid annular plane systolic excursion (HR = 1.18 per 1 mm decrease, p < 0.001) were associated with COVID-related mortality, but only GLS remained significant in fully adjusted analysis (HR = 1.14, p = 0.02). Conclusion: Reduced GLS was associated with COVID-related mortality independently of wave, treatment, and the SARS-CoV-2 variant. LV function was significantly impaired in patients hospitalized during the second wave.
AB - Introduction: COVID-19 has spread globally in waves, and Danish treatment guidelines have been updated following the first wave. We sought to investigate whether the prognostic values of echocardiographic parameters changed with updates in treatment guidelines and the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, 20E (EU1) and alpha (B.1.1.7), and further to compare cardiac parameters between patients from the first and second wave. Methods: A total of 305 patients hospitalized with COVID-19 were prospectively included, 215 and 90 during the first and second wave, respectively. Treatment in the study was defined as treatment with remdesivir, dexamethasone, or both. Patients were assumed to be infected with the dominant SARS-CoV-2 variant at the time of their hospitalization. Results: Mean age for the first versus second wave was 68.7 ± 13.6 versus 69.7 ± 15.8 years, and 55% versus 62% were males. Left ventricular (LV) systolic and diastolic function was worse in patients hospitalized during the second wave (LV ejection fraction [LVEF] for first vs. second wave = 58.5 ± 8.1% vs. 52.4 ± 10.6%, p < 0.001; and global longitudinal strain [GLS] = 16.4 ± 4.3% vs. 14.2 ± 4.3%, p < 0.001). In univariable Cox regressions, reduced LVEF (hazard ratio [HR] = 1.07 per 1% decrease, p = 0.002), GLS (HR = 1.21 per 1% decrease, p < 0.001), and tricuspid annular plane systolic excursion (HR = 1.18 per 1 mm decrease, p < 0.001) were associated with COVID-related mortality, but only GLS remained significant in fully adjusted analysis (HR = 1.14, p = 0.02). Conclusion: Reduced GLS was associated with COVID-related mortality independently of wave, treatment, and the SARS-CoV-2 variant. LV function was significantly impaired in patients hospitalized during the second wave.
KW - COVID-19
KW - Echocardiography
KW - Global longitudinal strain
KW - Prognostics
KW - Speckle-Tracking echocardiography
U2 - 10.1159/000528308
DO - 10.1159/000528308
M3 - Journal article
C2 - 36455539
AN - SCOPUS:85148772942
VL - 148
SP - 48
EP - 57
JO - Cardiologia
JF - Cardiologia
SN - 0008-6312
IS - 1
ER -
ID: 373548921