Can Plasma Volume Determination in Cirrhosis Be Replaced by an Algorithm Using Body Weight and Hematocrit?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Can Plasma Volume Determination in Cirrhosis Be Replaced by an Algorithm Using Body Weight and Hematocrit? / Nørskov, Martine Prütz; Mønsted, Thormod; Kimer, Nina; Damgaard, Morten; Møller, Søren.

In: Diagnostics, Vol. 14, No. 8, 835, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nørskov, MP, Mønsted, T, Kimer, N, Damgaard, M & Møller, S 2024, 'Can Plasma Volume Determination in Cirrhosis Be Replaced by an Algorithm Using Body Weight and Hematocrit?', Diagnostics, vol. 14, no. 8, 835. https://doi.org/10.3390/diagnostics14080835

APA

Nørskov, M. P., Mønsted, T., Kimer, N., Damgaard, M., & Møller, S. (2024). Can Plasma Volume Determination in Cirrhosis Be Replaced by an Algorithm Using Body Weight and Hematocrit? Diagnostics, 14(8), [835]. https://doi.org/10.3390/diagnostics14080835

Vancouver

Nørskov MP, Mønsted T, Kimer N, Damgaard M, Møller S. Can Plasma Volume Determination in Cirrhosis Be Replaced by an Algorithm Using Body Weight and Hematocrit? Diagnostics. 2024;14(8). 835. https://doi.org/10.3390/diagnostics14080835

Author

Nørskov, Martine Prütz ; Mønsted, Thormod ; Kimer, Nina ; Damgaard, Morten ; Møller, Søren. / Can Plasma Volume Determination in Cirrhosis Be Replaced by an Algorithm Using Body Weight and Hematocrit?. In: Diagnostics. 2024 ; Vol. 14, No. 8.

Bibtex

@article{22ccf97fd4df4a2386c827034cd26433,
title = "Can Plasma Volume Determination in Cirrhosis Be Replaced by an Algorithm Using Body Weight and Hematocrit?",
abstract = "Background: Patients with cirrhosis often develop hyperdynamic circulation with increased cardiac output, heart rate, and redistribution of the circulating volume with expanded plasma volume (PV). PV determination is part of the evaluation of patients with cirrhosis, but gold-standard methods are invasive, expensive, and time-consuming. Therefore, other estimations of PV would be preferable, and the aim of this study was therefore to study if PV, as assessed by a simplified algorithm based on hematocrit and weight, can replace the gold-standard method. Methods: We included 328 patients with cirrhosis who had their PV assessed by the indicator dilution technique as the gold-standard method (PVI-125). Actual PV was estimated as PVa = (1 − hematocrit)·(a + (b·body weight)). Ideal PV was estimated as PVi = c · body weight, where a, b, and c are constants. Results: PVI-125, PVa, and PVi were 3.99 ± 1.01, 3.09 ± 0.54, and 3.01 ± 0.65 (Mean ± SD), respectively. Although PVI-125 correlated significantly with PVa (r = 0.72, p < 0.001), a Bland–Altman plot revealed wide limits of confidence. Conclusions: The use of simplified algorithms does not sufficiently estimate PV and cannot replace the indicator dilution technique.",
keywords = "calculated plasma volume, cirrhosis, plasma volume, portal hypertension",
author = "N{\o}rskov, {Martine Pr{\"u}tz} and Thormod M{\o}nsted and Nina Kimer and Morten Damgaard and S{\o}ren M{\o}ller",
note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",
year = "2024",
doi = "10.3390/diagnostics14080835",
language = "English",
volume = "14",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "MDPI AG",
number = "8",

}

RIS

TY - JOUR

T1 - Can Plasma Volume Determination in Cirrhosis Be Replaced by an Algorithm Using Body Weight and Hematocrit?

AU - Nørskov, Martine Prütz

AU - Mønsted, Thormod

AU - Kimer, Nina

AU - Damgaard, Morten

AU - Møller, Søren

N1 - Publisher Copyright: © 2024 by the authors.

PY - 2024

Y1 - 2024

N2 - Background: Patients with cirrhosis often develop hyperdynamic circulation with increased cardiac output, heart rate, and redistribution of the circulating volume with expanded plasma volume (PV). PV determination is part of the evaluation of patients with cirrhosis, but gold-standard methods are invasive, expensive, and time-consuming. Therefore, other estimations of PV would be preferable, and the aim of this study was therefore to study if PV, as assessed by a simplified algorithm based on hematocrit and weight, can replace the gold-standard method. Methods: We included 328 patients with cirrhosis who had their PV assessed by the indicator dilution technique as the gold-standard method (PVI-125). Actual PV was estimated as PVa = (1 − hematocrit)·(a + (b·body weight)). Ideal PV was estimated as PVi = c · body weight, where a, b, and c are constants. Results: PVI-125, PVa, and PVi were 3.99 ± 1.01, 3.09 ± 0.54, and 3.01 ± 0.65 (Mean ± SD), respectively. Although PVI-125 correlated significantly with PVa (r = 0.72, p < 0.001), a Bland–Altman plot revealed wide limits of confidence. Conclusions: The use of simplified algorithms does not sufficiently estimate PV and cannot replace the indicator dilution technique.

AB - Background: Patients with cirrhosis often develop hyperdynamic circulation with increased cardiac output, heart rate, and redistribution of the circulating volume with expanded plasma volume (PV). PV determination is part of the evaluation of patients with cirrhosis, but gold-standard methods are invasive, expensive, and time-consuming. Therefore, other estimations of PV would be preferable, and the aim of this study was therefore to study if PV, as assessed by a simplified algorithm based on hematocrit and weight, can replace the gold-standard method. Methods: We included 328 patients with cirrhosis who had their PV assessed by the indicator dilution technique as the gold-standard method (PVI-125). Actual PV was estimated as PVa = (1 − hematocrit)·(a + (b·body weight)). Ideal PV was estimated as PVi = c · body weight, where a, b, and c are constants. Results: PVI-125, PVa, and PVi were 3.99 ± 1.01, 3.09 ± 0.54, and 3.01 ± 0.65 (Mean ± SD), respectively. Although PVI-125 correlated significantly with PVa (r = 0.72, p < 0.001), a Bland–Altman plot revealed wide limits of confidence. Conclusions: The use of simplified algorithms does not sufficiently estimate PV and cannot replace the indicator dilution technique.

KW - calculated plasma volume

KW - cirrhosis

KW - plasma volume

KW - portal hypertension

U2 - 10.3390/diagnostics14080835

DO - 10.3390/diagnostics14080835

M3 - Journal article

C2 - 38667480

AN - SCOPUS:85191708528

VL - 14

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 8

M1 - 835

ER -

ID: 391211164