Brain tumours in children and adolescents may affect the circadian rhythm and quality of life
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Brain tumours in children and adolescents may affect the circadian rhythm and quality of life. / Pickering, Line; Main, Katharina M.; Feldt-Rasmussen, Ulla; Klose, Marianne; Sehested, Astrid; Mathiasen, René; Jennum, Poul.
In: Acta Paediatrica, Vol. 110, No. 12, 2021, p. 3376-3386.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Brain tumours in children and adolescents may affect the circadian rhythm and quality of life
AU - Pickering, Line
AU - Main, Katharina M.
AU - Feldt-Rasmussen, Ulla
AU - Klose, Marianne
AU - Sehested, Astrid
AU - Mathiasen, René
AU - Jennum, Poul
PY - 2021
Y1 - 2021
N2 - AimChildren with brain and cervical medulla tumours may experience circadian abnormalities and poor health. We aimed to examine their circadian rhythm, fatigue and quality of life (QoL).MethodsChildren with a brain or cervical medulla tumour were recruited from the Paediatric Department, Rigshospitalet, Copenhagen, Denmark, between 2016 and 2020. They were grouped by tumour location involving the circadian regulatory system, defined as diencephalon, pineal gland, brain stem and cervical medulla, or other areas. Saliva melatonin and cortisol concentrations were measured. Sleep diaries and actigraphy assessed sleep-wake patterns. The Pediatric Quality of Life Inventory, Multidimensional Fatigue Scale and Generic Core Scale measured fatigue and QoL.ResultsWe included 68 children (62% males) with a median age (25th-75th percentiles) of 12.2 (7.7–16.3) years. Children with tumours involving the circadian regulatory system typically had a lower melatonin peak (p=0.06) and experienced significantly more fatigue and poorer QoL. Low melatonin profiles were observed in 31% and 4% had a phase-shifted daytime peak, compared with 14% and 0%, respectively, in children with tumours located elsewhere. Children with low melatonin profiles had significantly lower inter-daily stability than those with normal profiles.ConclusionTumours involving the circadian regulatory system adversely affected circadian function, fatigue and QoL.
AB - AimChildren with brain and cervical medulla tumours may experience circadian abnormalities and poor health. We aimed to examine their circadian rhythm, fatigue and quality of life (QoL).MethodsChildren with a brain or cervical medulla tumour were recruited from the Paediatric Department, Rigshospitalet, Copenhagen, Denmark, between 2016 and 2020. They were grouped by tumour location involving the circadian regulatory system, defined as diencephalon, pineal gland, brain stem and cervical medulla, or other areas. Saliva melatonin and cortisol concentrations were measured. Sleep diaries and actigraphy assessed sleep-wake patterns. The Pediatric Quality of Life Inventory, Multidimensional Fatigue Scale and Generic Core Scale measured fatigue and QoL.ResultsWe included 68 children (62% males) with a median age (25th-75th percentiles) of 12.2 (7.7–16.3) years. Children with tumours involving the circadian regulatory system typically had a lower melatonin peak (p=0.06) and experienced significantly more fatigue and poorer QoL. Low melatonin profiles were observed in 31% and 4% had a phase-shifted daytime peak, compared with 14% and 0%, respectively, in children with tumours located elsewhere. Children with low melatonin profiles had significantly lower inter-daily stability than those with normal profiles.ConclusionTumours involving the circadian regulatory system adversely affected circadian function, fatigue and QoL.
KW - Central nervous system tumour
KW - circadian rhythm
KW - cortisol
KW - melatonin
KW - quality of life
KW - Central nervous system tumour
KW - circadian rhythm
KW - cortisol
KW - melatonin
KW - quality of life
U2 - 10.1111/apa.16080
DO - 10.1111/apa.16080
M3 - Journal article
C2 - 34432900
VL - 110
SP - 3376
EP - 3386
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 12
ER -
ID: 279649736