Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat
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Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat. / Juhler, M; Barry, D I; Offner, H; Konat, G; Klinken, Leif; Paulson, O B.
In: Brain Research, Vol. 302, No. 2, 08.06.1984, p. 347-55.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat
AU - Juhler, M
AU - Barry, D I
AU - Offner, H
AU - Konat, G
AU - Klinken, Leif
AU - Paulson, O B
PY - 1984/6/8
Y1 - 1984/6/8
N2 - Experimental allergic encephalomyelitis (EAE) was induced in young male Lewis rats. Blood-brain barrier permeability to radiotracers of different molecular sizes was studied at intervals after induction using a tissue sampling technique. The results were correlated to the clinical picture and to the histological appearance of the central nervous system. Significant increase in blood-brain barrier permeability to small molecules was found to precede clinical symptoms by one day in the lumbar spinal cord and to coincide with the onset of clinical disease in other regions. In all regions, increased blood-brain barrier permeability preceded the occurrence of histological lesions (perivascular cellular infiltrates). No permeability increase to large molecules could be demonstrated.
AB - Experimental allergic encephalomyelitis (EAE) was induced in young male Lewis rats. Blood-brain barrier permeability to radiotracers of different molecular sizes was studied at intervals after induction using a tissue sampling technique. The results were correlated to the clinical picture and to the histological appearance of the central nervous system. Significant increase in blood-brain barrier permeability to small molecules was found to precede clinical symptoms by one day in the lumbar spinal cord and to coincide with the onset of clinical disease in other regions. In all regions, increased blood-brain barrier permeability preceded the occurrence of histological lesions (perivascular cellular infiltrates). No permeability increase to large molecules could be demonstrated.
KW - Animals
KW - Blood-Brain Barrier
KW - Brain/pathology
KW - Capillary Permeability
KW - Chlorides/metabolism
KW - Encephalomyelitis, Autoimmune, Experimental/metabolism
KW - Inulin/metabolism
KW - Male
KW - Myelin Proteins/metabolism
KW - Nerve Fibers, Myelinated/ultrastructure
KW - Rats
KW - Rats, Inbred Lew
KW - Sodium/metabolism
KW - Spinal Cord/metabolism
KW - Sucrose/metabolism
U2 - 10.1016/0006-8993(84)90249-x
DO - 10.1016/0006-8993(84)90249-x
M3 - Journal article
C2 - 6610460
VL - 302
SP - 347
EP - 355
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -
ID: 279595011