Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. / Nielsen, S. E.; Breinholt, V.; Cornett, Claus; Dragsted, L. O.
In: Food and Chemical Toxicology, Vol. 38, No. 9, 2000, p. 739-746.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus
AU - Nielsen, S. E.
AU - Breinholt, V.
AU - Cornett, Claus
AU - Dragsted, L. O.
PY - 2000
Y1 - 2000
N2 - The present study mas carried out in order to investigate the in vivo biotransformation and excretion of the flavone, tangeretin, found in citrus fruits, by analysing urine and faeces samples from rats after repeated administration of 100 mg/kg body weight/day tangeretin. The formed metabolites were separated and identified by HPLC and the structures elucidated by LC/MS and H-1 NMR. Ten new, major metabolites with intact flavonoid structure were identified. The metabolites identified were either demethylated or hydroxylated derivatives of the parent compound and metabolic changes were found primarily to occur in the 4' position of the B-ring. The total urinary excretion of tangeretin metabolites with intact flavan nucleus sas about 11% of the administered daily dose. (C) 2000 Elsevier Science Ltd. All rights reserved.
AB - The present study mas carried out in order to investigate the in vivo biotransformation and excretion of the flavone, tangeretin, found in citrus fruits, by analysing urine and faeces samples from rats after repeated administration of 100 mg/kg body weight/day tangeretin. The formed metabolites were separated and identified by HPLC and the structures elucidated by LC/MS and H-1 NMR. Ten new, major metabolites with intact flavonoid structure were identified. The metabolites identified were either demethylated or hydroxylated derivatives of the parent compound and metabolic changes were found primarily to occur in the 4' position of the B-ring. The total urinary excretion of tangeretin metabolites with intact flavan nucleus sas about 11% of the administered daily dose. (C) 2000 Elsevier Science Ltd. All rights reserved.
KW - tangeretin rat citrus flavone metabolism HPLC liver epithelial-cells intercellular communication inhibition microsomes quercetin apigenin antioxidants biomarkers excretion enzymes
M3 - Tidsskriftartikel
VL - 38
SP - 739
EP - 746
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
SN - 0278-6915
IS - 9
ER -
ID: 38061998