Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications
Research output: Contribution to journal › Review › Research › peer-review
Standard
Axonal transport defects and neurodegeneration : Molecular mechanisms and therapeutic implications. / Guo, Wenting; Stoklund Dittlau, Katarina; Van Den Bosch, Ludo.
In: Seminars in Cell and Developmental Biology, Vol. 99, 2020, p. 133-150.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Axonal transport defects and neurodegeneration
T2 - Molecular mechanisms and therapeutic implications
AU - Guo, Wenting
AU - Stoklund Dittlau, Katarina
AU - Van Den Bosch, Ludo
N1 - Publisher Copyright: © 2019 The Authors
PY - 2020
Y1 - 2020
N2 - Because of the extremely polarized morphology, the proper functioning of neurons largely relies on the efficient cargo transport along the axon. Axonal transport defects have been reported in multiple neurodegenerative diseases as an early pathological feature. The discovery of mutations in human genes involved in the transport machinery provide a direct causative relationship between axonal transport defects and neurodegeneration. Here, we summarize the current genetic findings related to axonal transport in neurodegenerative diseases, and we discuss the relationship between axonal transport defects and other pathological changes observed in neurodegeneration. In addition, we summarize the therapeutic approaches targeting the axonal transport machinery in studies of neurodegenerative diseases. Finally, we review the technical advances in tracking axonal transport both in vivo and in vitro.
AB - Because of the extremely polarized morphology, the proper functioning of neurons largely relies on the efficient cargo transport along the axon. Axonal transport defects have been reported in multiple neurodegenerative diseases as an early pathological feature. The discovery of mutations in human genes involved in the transport machinery provide a direct causative relationship between axonal transport defects and neurodegeneration. Here, we summarize the current genetic findings related to axonal transport in neurodegenerative diseases, and we discuss the relationship between axonal transport defects and other pathological changes observed in neurodegeneration. In addition, we summarize the therapeutic approaches targeting the axonal transport machinery in studies of neurodegenerative diseases. Finally, we review the technical advances in tracking axonal transport both in vivo and in vitro.
KW - Amyotrophic lateral sclerosis
KW - Axonal transport
KW - Neurodegenerative diseases
KW - Peripheral neuropathy
U2 - 10.1016/j.semcdb.2019.07.010
DO - 10.1016/j.semcdb.2019.07.010
M3 - Review
C2 - 31542222
AN - SCOPUS:85072261132
VL - 99
SP - 133
EP - 150
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
ER -
ID: 368623300