Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates
Research output: Contribution to journal › Journal article › Research › peer-review
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Author's View : a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates. / Taskin, Asli Aras; Poveda-Huertes, Daniel; Vögtle, F-Nora.
In: Molecular & Cellular Oncology, Vol. 7, No. 1, 1698256, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Author's View
T2 - a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates
AU - Taskin, Asli Aras
AU - Poveda-Huertes, Daniel
AU - Vögtle, F-Nora
N1 - © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2020
Y1 - 2020
N2 - Mitochondrial proteostasis is essential for survival, and imbalances can result in severe human diseases. We identified a novel stress response triggered upon accumulation of proteotoxic aggregates in the mitochondrial matrix. Mitochondria-to-nucleus signaling results in a transcriptional response and translocation of a nuclear transcription factor into mitochondria to maintain mitochondrial gene expression.
AB - Mitochondrial proteostasis is essential for survival, and imbalances can result in severe human diseases. We identified a novel stress response triggered upon accumulation of proteotoxic aggregates in the mitochondrial matrix. Mitochondria-to-nucleus signaling results in a transcriptional response and translocation of a nuclear transcription factor into mitochondria to maintain mitochondrial gene expression.
U2 - 10.1080/23723556.2019.1698256
DO - 10.1080/23723556.2019.1698256
M3 - Journal article
C2 - 31993502
VL - 7
JO - Molecular & Cellular Oncology
JF - Molecular & Cellular Oncology
SN - 2372-3556
IS - 1
M1 - 1698256
ER -
ID: 391634591