Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans

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Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans. / Joergensen, Anders; Broedbaek, Kasper; Weimann, Allan; Semba, Richard D; Ferrucci, Luigi; Joergensen, Martin B; Poulsen, Henrik E.

In: P L o S One, Vol. 6, No. 6, 01.01.2011, p. e20795.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Joergensen, A, Broedbaek, K, Weimann, A, Semba, RD, Ferrucci, L, Joergensen, MB & Poulsen, HE 2011, 'Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans', P L o S One, vol. 6, no. 6, pp. e20795. https://doi.org/10.1371/journal.pone.0020795, https://doi.org/10.1371/journal.pone.0020795

APA

Joergensen, A., Broedbaek, K., Weimann, A., Semba, R. D., Ferrucci, L., Joergensen, M. B., & Poulsen, H. E. (2011). Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans. P L o S One, 6(6), e20795. https://doi.org/10.1371/journal.pone.0020795, https://doi.org/10.1371/journal.pone.0020795

Vancouver

Joergensen A, Broedbaek K, Weimann A, Semba RD, Ferrucci L, Joergensen MB et al. Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans. P L o S One. 2011 Jan 1;6(6):e20795. https://doi.org/10.1371/journal.pone.0020795, https://doi.org/10.1371/journal.pone.0020795

Author

Joergensen, Anders ; Broedbaek, Kasper ; Weimann, Allan ; Semba, Richard D ; Ferrucci, Luigi ; Joergensen, Martin B ; Poulsen, Henrik E. / Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans. In: P L o S One. 2011 ; Vol. 6, No. 6. pp. e20795.

Bibtex

@article{c081e51edcce4db8bddf03273c1c4d3d,
title = "Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans",
abstract = "Chronic psychological stress is associated with accelerated aging, but the underlying biological mechanisms are not known. Prolonged elevations of the stress hormone cortisol is suspected to play a critical role. Through its actions, cortisol may potentially induce oxidatively generated damage to cellular constituents such as DNA and RNA, a phenomenon which has been implicated in aging processes. We investigated the relationship between 24 h excretion of urinary cortisol and markers of oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, in a sample of 220 elderly men and women (age 65 - 83 years). We found a robust association between the excretion of cortisol and the oxidation markers (R(2)¿=¿0.15, P",
author = "Anders Joergensen and Kasper Broedbaek and Allan Weimann and Semba, {Richard D} and Luigi Ferrucci and Joergensen, {Martin B} and Poulsen, {Henrik E}",
year = "2011",
month = jan,
day = "1",
doi = "10.1371/journal.pone.0020795",
language = "English",
volume = "6",
pages = "e20795",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

RIS

TY - JOUR

T1 - Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans

AU - Joergensen, Anders

AU - Broedbaek, Kasper

AU - Weimann, Allan

AU - Semba, Richard D

AU - Ferrucci, Luigi

AU - Joergensen, Martin B

AU - Poulsen, Henrik E

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Chronic psychological stress is associated with accelerated aging, but the underlying biological mechanisms are not known. Prolonged elevations of the stress hormone cortisol is suspected to play a critical role. Through its actions, cortisol may potentially induce oxidatively generated damage to cellular constituents such as DNA and RNA, a phenomenon which has been implicated in aging processes. We investigated the relationship between 24 h excretion of urinary cortisol and markers of oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, in a sample of 220 elderly men and women (age 65 - 83 years). We found a robust association between the excretion of cortisol and the oxidation markers (R(2)¿=¿0.15, P

AB - Chronic psychological stress is associated with accelerated aging, but the underlying biological mechanisms are not known. Prolonged elevations of the stress hormone cortisol is suspected to play a critical role. Through its actions, cortisol may potentially induce oxidatively generated damage to cellular constituents such as DNA and RNA, a phenomenon which has been implicated in aging processes. We investigated the relationship between 24 h excretion of urinary cortisol and markers of oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, in a sample of 220 elderly men and women (age 65 - 83 years). We found a robust association between the excretion of cortisol and the oxidation markers (R(2)¿=¿0.15, P

U2 - 10.1371/journal.pone.0020795

DO - 10.1371/journal.pone.0020795

M3 - Journal article

C2 - 21687734

VL - 6

SP - e20795

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 6

ER -

ID: 34090517