Association between the intake of α-linolenic acid and the risk of CHD
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Association between the intake of α-linolenic acid and the risk of CHD. / Vedtofte, Mia Sadowa; Jakobsen, Marianne U; Lauritzen, Lotte; O'Reilly, Eilis J; Virtamo, Jarmo; Knekt, Paul; Colditz, Graham; Hallmans, Göran; Buring, Julie; Steffen, Lyn M; Robien, Kimberly; Rimm, Eric B; Heitmann, Berit L.
In: British Journal of Nutrition, Vol. 112, No. 5, 2014, p. 735-743.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Association between the intake of α-linolenic acid and the risk of CHD
AU - Vedtofte, Mia Sadowa
AU - Jakobsen, Marianne U
AU - Lauritzen, Lotte
AU - O'Reilly, Eilis J
AU - Virtamo, Jarmo
AU - Knekt, Paul
AU - Colditz, Graham
AU - Hallmans, Göran
AU - Buring, Julie
AU - Steffen, Lyn M
AU - Robien, Kimberly
AU - Rimm, Eric B
AU - Heitmann, Berit L
N1 - CURSI 2014 NEXS 210
PY - 2014
Y1 - 2014
N2 - The intake of the mainly plant-derived n-3 PUFA α-linolenic acid (ALA) has been reported to be associated with a lower risk of CHD. However, the results have been inconsistent. Therefore, the objective of the present study was to examine the association between the intake of ALA and the risk of CHD. Potential effect modification by the intake of long-chain n-3 PUFA (n-3 LCPUFA) was also investigated. Data from eight American and European prospective cohort studies including 148 675 women and 80 368 men were used. The outcome measure was incident CHD (CHD event and death). During 4-10 years of follow-up, 4493 CHD events and 1751 CHD deaths occurred. Among men, an inverse association (not significant) between the intake of ALA and the risk of CHD events and deaths was observed. For each additional gram of ALA consumed, a 15 % lower risk of CHD events (hazard ratios (HR) 0·85, 95 % CI 0·72, 1·01) and a 23 % lower risk of CHD deaths (HR 0·77, 95 % CI 0·58, 1·01) were observed. No consistent association was observed among women. No effect modification by the intake of n-3 LCPUFA was observed.
AB - The intake of the mainly plant-derived n-3 PUFA α-linolenic acid (ALA) has been reported to be associated with a lower risk of CHD. However, the results have been inconsistent. Therefore, the objective of the present study was to examine the association between the intake of ALA and the risk of CHD. Potential effect modification by the intake of long-chain n-3 PUFA (n-3 LCPUFA) was also investigated. Data from eight American and European prospective cohort studies including 148 675 women and 80 368 men were used. The outcome measure was incident CHD (CHD event and death). During 4-10 years of follow-up, 4493 CHD events and 1751 CHD deaths occurred. Among men, an inverse association (not significant) between the intake of ALA and the risk of CHD events and deaths was observed. For each additional gram of ALA consumed, a 15 % lower risk of CHD events (hazard ratios (HR) 0·85, 95 % CI 0·72, 1·01) and a 23 % lower risk of CHD deaths (HR 0·77, 95 % CI 0·58, 1·01) were observed. No consistent association was observed among women. No effect modification by the intake of n-3 LCPUFA was observed.
U2 - 10.1017/S000711451400138X
DO - 10.1017/S000711451400138X
M3 - Journal article
C2 - 24964401
VL - 112
SP - 735
EP - 743
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 5
ER -
ID: 120017990