Association between early risk factors and level of functioning at age seven in children at familial risk for schizophrenia or bipolar disorder - The Danish High Risk and Resilience Study VIA 7

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Association between early risk factors and level of functioning at age seven in children at familial risk for schizophrenia or bipolar disorder - The Danish High Risk and Resilience Study VIA 7. / Bundgaard, Anette Faurskov; Hemager, Nicoline; Gantriis, Ditte Lou; Steffensen, Nanna Lawaetz; Burton, Birgitte Klee; Ellersgaard, Ditte; Christiani, Camilla Jerlang; Spang, Katrine S.; Carlsen, Anders Helles; Bliksted, Vibeke; Plessen, Kerstin J.; Jepsen, Jens Richardt Mollegaard; Nordentoft, Merete; Mors, Ole; Thorup, Anne A. E.; Greve, Aja Neergaard.

In: Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, Vol. 10, No. 1, 2022, p. 12-23.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bundgaard, AF, Hemager, N, Gantriis, DL, Steffensen, NL, Burton, BK, Ellersgaard, D, Christiani, CJ, Spang, KS, Carlsen, AH, Bliksted, V, Plessen, KJ, Jepsen, JRM, Nordentoft, M, Mors, O, Thorup, AAE & Greve, AN 2022, 'Association between early risk factors and level of functioning at age seven in children at familial risk for schizophrenia or bipolar disorder - The Danish High Risk and Resilience Study VIA 7', Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, vol. 10, no. 1, pp. 12-23. https://doi.org/10.2478/sjcapp-2022-0001

APA

Bundgaard, A. F., Hemager, N., Gantriis, D. L., Steffensen, N. L., Burton, B. K., Ellersgaard, D., Christiani, C. J., Spang, K. S., Carlsen, A. H., Bliksted, V., Plessen, K. J., Jepsen, J. R. M., Nordentoft, M., Mors, O., Thorup, A. A. E., & Greve, A. N. (2022). Association between early risk factors and level of functioning at age seven in children at familial risk for schizophrenia or bipolar disorder - The Danish High Risk and Resilience Study VIA 7. Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 10(1), 12-23. https://doi.org/10.2478/sjcapp-2022-0001

Vancouver

Bundgaard AF, Hemager N, Gantriis DL, Steffensen NL, Burton BK, Ellersgaard D et al. Association between early risk factors and level of functioning at age seven in children at familial risk for schizophrenia or bipolar disorder - The Danish High Risk and Resilience Study VIA 7. Scandinavian Journal of Child and Adolescent Psychiatry and Psychology. 2022;10(1):12-23. https://doi.org/10.2478/sjcapp-2022-0001

Author

Bundgaard, Anette Faurskov ; Hemager, Nicoline ; Gantriis, Ditte Lou ; Steffensen, Nanna Lawaetz ; Burton, Birgitte Klee ; Ellersgaard, Ditte ; Christiani, Camilla Jerlang ; Spang, Katrine S. ; Carlsen, Anders Helles ; Bliksted, Vibeke ; Plessen, Kerstin J. ; Jepsen, Jens Richardt Mollegaard ; Nordentoft, Merete ; Mors, Ole ; Thorup, Anne A. E. ; Greve, Aja Neergaard. / Association between early risk factors and level of functioning at age seven in children at familial risk for schizophrenia or bipolar disorder - The Danish High Risk and Resilience Study VIA 7. In: Scandinavian Journal of Child and Adolescent Psychiatry and Psychology. 2022 ; Vol. 10, No. 1. pp. 12-23.

Bibtex

@article{7cd89b8b6d4c407db31b1c99318137f5,
title = "Association between early risk factors and level of functioning at age seven in children at familial risk for schizophrenia or bipolar disorder - The Danish High Risk and Resilience Study VIA 7",
abstract = "Background: Facing multiple risk factors, relative to single risk factor exposure early in life can have great implications for negative child development.Objective: We aim to examine whether the prevalence of early risk factors is higher among children with familial high risk for schizophrenia or bipolar disorder compared to controls. Further, to investigate the association between number of early risk factors and level of functioning at age seven, and whether this possible association is different in children with familial high risk compared to controls.Method: The Danish High Risk and Resilience Study VIA 7 is a population-based cohort study of children of parents diagnosed with schizophrenia (N = 202), bipolar disorder (N = 120) and controls (N = 200). We conducted a semi-structured anamnestic interview with the child's primary caregiver to assess early risk factors from pregnancy to age four. We used the Children's Global Assessment Scale to measure level of functioning at age seven.Results: 13 out of 17 risk factors were more prevalent in children at familial high risk for schizophrenia and 7 out of 17 risk factors were more prevalent in children at familial high risk for bipolar disorder compared to controls. Level of functioning decreased 2.7 (95% CI, 2.2; 3.3)-points per risk factor, but the association was not significantly different across the three groups (p = 0.09).Conclusions: Our results showed that children at age seven with familial high risk for schizophrenia or bipolar disorder experience a greater number of early risk factors. A higher number of early risk factors were associated with lower level of functioning at age seven. However, the association is not different for children with familial high risk or controls.",
keywords = "risk factors, cumulative risk, familial high risk, schizophrenia, bipolar disorder, CUMULATIVE RISK, 7-YEAR-OLD CHILDREN, MATERNAL STRESS, CHILDHOOD, PREGNANCY, POPULATION, BEHAVIOR, PSYCHOPATHOLOGY, STIMULATION, WANTEDNESS",
author = "Bundgaard, {Anette Faurskov} and Nicoline Hemager and Gantriis, {Ditte Lou} and Steffensen, {Nanna Lawaetz} and Burton, {Birgitte Klee} and Ditte Ellersgaard and Christiani, {Camilla Jerlang} and Spang, {Katrine S.} and Carlsen, {Anders Helles} and Vibeke Bliksted and Plessen, {Kerstin J.} and Jepsen, {Jens Richardt Mollegaard} and Merete Nordentoft and Ole Mors and Thorup, {Anne A. E.} and Greve, {Aja Neergaard}",
year = "2022",
doi = "10.2478/sjcapp-2022-0001",
language = "English",
volume = "10",
pages = "12--23",
journal = "Scandinavian Journal of Child and Adolescent Psychiatry and Psychology",
issn = "2245-8875",
publisher = "Psykiatrisk foskningsafsnit, Region Sj{\ae}lland",
number = "1",

}

RIS

TY - JOUR

T1 - Association between early risk factors and level of functioning at age seven in children at familial risk for schizophrenia or bipolar disorder - The Danish High Risk and Resilience Study VIA 7

AU - Bundgaard, Anette Faurskov

AU - Hemager, Nicoline

AU - Gantriis, Ditte Lou

AU - Steffensen, Nanna Lawaetz

AU - Burton, Birgitte Klee

AU - Ellersgaard, Ditte

AU - Christiani, Camilla Jerlang

AU - Spang, Katrine S.

AU - Carlsen, Anders Helles

AU - Bliksted, Vibeke

AU - Plessen, Kerstin J.

AU - Jepsen, Jens Richardt Mollegaard

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Thorup, Anne A. E.

AU - Greve, Aja Neergaard

PY - 2022

Y1 - 2022

N2 - Background: Facing multiple risk factors, relative to single risk factor exposure early in life can have great implications for negative child development.Objective: We aim to examine whether the prevalence of early risk factors is higher among children with familial high risk for schizophrenia or bipolar disorder compared to controls. Further, to investigate the association between number of early risk factors and level of functioning at age seven, and whether this possible association is different in children with familial high risk compared to controls.Method: The Danish High Risk and Resilience Study VIA 7 is a population-based cohort study of children of parents diagnosed with schizophrenia (N = 202), bipolar disorder (N = 120) and controls (N = 200). We conducted a semi-structured anamnestic interview with the child's primary caregiver to assess early risk factors from pregnancy to age four. We used the Children's Global Assessment Scale to measure level of functioning at age seven.Results: 13 out of 17 risk factors were more prevalent in children at familial high risk for schizophrenia and 7 out of 17 risk factors were more prevalent in children at familial high risk for bipolar disorder compared to controls. Level of functioning decreased 2.7 (95% CI, 2.2; 3.3)-points per risk factor, but the association was not significantly different across the three groups (p = 0.09).Conclusions: Our results showed that children at age seven with familial high risk for schizophrenia or bipolar disorder experience a greater number of early risk factors. A higher number of early risk factors were associated with lower level of functioning at age seven. However, the association is not different for children with familial high risk or controls.

AB - Background: Facing multiple risk factors, relative to single risk factor exposure early in life can have great implications for negative child development.Objective: We aim to examine whether the prevalence of early risk factors is higher among children with familial high risk for schizophrenia or bipolar disorder compared to controls. Further, to investigate the association between number of early risk factors and level of functioning at age seven, and whether this possible association is different in children with familial high risk compared to controls.Method: The Danish High Risk and Resilience Study VIA 7 is a population-based cohort study of children of parents diagnosed with schizophrenia (N = 202), bipolar disorder (N = 120) and controls (N = 200). We conducted a semi-structured anamnestic interview with the child's primary caregiver to assess early risk factors from pregnancy to age four. We used the Children's Global Assessment Scale to measure level of functioning at age seven.Results: 13 out of 17 risk factors were more prevalent in children at familial high risk for schizophrenia and 7 out of 17 risk factors were more prevalent in children at familial high risk for bipolar disorder compared to controls. Level of functioning decreased 2.7 (95% CI, 2.2; 3.3)-points per risk factor, but the association was not significantly different across the three groups (p = 0.09).Conclusions: Our results showed that children at age seven with familial high risk for schizophrenia or bipolar disorder experience a greater number of early risk factors. A higher number of early risk factors were associated with lower level of functioning at age seven. However, the association is not different for children with familial high risk or controls.

KW - risk factors

KW - cumulative risk

KW - familial high risk

KW - schizophrenia

KW - bipolar disorder

KW - CUMULATIVE RISK

KW - 7-YEAR-OLD CHILDREN

KW - MATERNAL STRESS

KW - CHILDHOOD

KW - PREGNANCY

KW - POPULATION

KW - BEHAVIOR

KW - PSYCHOPATHOLOGY

KW - STIMULATION

KW - WANTEDNESS

U2 - 10.2478/sjcapp-2022-0001

DO - 10.2478/sjcapp-2022-0001

M3 - Journal article

C2 - 36341275

VL - 10

SP - 12

EP - 23

JO - Scandinavian Journal of Child and Adolescent Psychiatry and Psychology

JF - Scandinavian Journal of Child and Adolescent Psychiatry and Psychology

SN - 2245-8875

IS - 1

ER -

ID: 344438347