Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells
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Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells. / Nielsen, J.R.; Hansen, Harald S.; Jensen, B.
In: F E B S Letters, Vol. 218, No. 1, 01.01.1987, p. 93-96.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Arginine-vasopressin stimulates the formation of phosphatidic acid in rat Leydig cells
AU - Nielsen, J.R.
AU - Hansen, Harald S.
AU - Jensen, B.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - Arginine-vasopressin (AVP) stimulated the formation of labelled phosphatidic acid (PA) in [C]arachidonic acid-prelabelled rat Leydig cells. After addition of 10 M AVP [C]arachidonoylphosphatidic acid reached a maximum within 2 min. The increase was dose-dependent (10-10 M). No change in labelling of other phospholipids and diacylglycerol could be detected. The V antagonist dPTyr(Me)AVP inhibited in a dose-dependent manner the AVP-stimulated accumulation of PA. The V agonist dPVDAVP was without effect. The present results suggest that AVP binds to V receptors in rat Leydig cells resulting in stimulation of PA turnover. We suggest that the AVP-stimulated PA formation is an indication of phosphoinositide turnover.
AB - Arginine-vasopressin (AVP) stimulated the formation of labelled phosphatidic acid (PA) in [C]arachidonic acid-prelabelled rat Leydig cells. After addition of 10 M AVP [C]arachidonoylphosphatidic acid reached a maximum within 2 min. The increase was dose-dependent (10-10 M). No change in labelling of other phospholipids and diacylglycerol could be detected. The V antagonist dPTyr(Me)AVP inhibited in a dose-dependent manner the AVP-stimulated accumulation of PA. The V agonist dPVDAVP was without effect. The present results suggest that AVP binds to V receptors in rat Leydig cells resulting in stimulation of PA turnover. We suggest that the AVP-stimulated PA formation is an indication of phosphoinositide turnover.
UR - http://www.scopus.com/inward/record.url?scp=0023179164&partnerID=8YFLogxK
M3 - Journal article
AN - SCOPUS:0023179164
VL - 218
SP - 93
EP - 96
JO - F E B S Letters
JF - F E B S Letters
SN - 0014-5793
IS - 1
ER -
ID: 45562649