Are Prolonged Ventricular Pauses in Atrial Fibrillation a Marker of Poor Prognosis?
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Are Prolonged Ventricular Pauses in Atrial Fibrillation a Marker of Poor Prognosis? / Stavnem, Dorte Marie; Hadad, Rakin; Larsen, Bjørn Strøier; Nielsen, Olav Wendelboe; Frederiksen, Mark Aplin; Davidsen, Ulla; Højbjerg, Søren; Karlsen, Finn Michael; Vall-Lamora, Maria Helena Domínguez; Rasmusen, Hanne Kruuse; Sajadieh, Ahmad.
In: Cardiology, Vol. 147, 2022, p. 57–61.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Are Prolonged Ventricular Pauses in Atrial Fibrillation a Marker of Poor Prognosis?
AU - Stavnem, Dorte Marie
AU - Hadad, Rakin
AU - Larsen, Bjørn Strøier
AU - Nielsen, Olav Wendelboe
AU - Frederiksen, Mark Aplin
AU - Davidsen, Ulla
AU - Højbjerg, Søren
AU - Karlsen, Finn Michael
AU - Vall-Lamora, Maria Helena Domínguez
AU - Rasmusen, Hanne Kruuse
AU - Sajadieh, Ahmad
PY - 2022
Y1 - 2022
N2 - Background: In patients with atrial fibrillation (AF), the long-term prognosis of long electrocardiographic pauses in the ventricular action is not well studied. Methods: Consecutive Holter recordings in patients with AF (n = 200) between 2009 and 2011 were evaluated, focusing on pauses of at least 2.5 s. Outcomes of interest were all-cause mortality and pacemaker implantation. Results: Forty-three patients (21.5%) had pauses with a mean of 3.2 s and an SD of 0.9 s. After a median follow-up of 99 months (ranging 89–111), 47% (20/43) of the patients with and 45% (70/157) without pauses were deceased. Pauses of ≥2.5 s did not constitute a risk of increased mortality: HR = 0.75 (95% CI: 0.34–1.66); p = 0.48, neither did pauses of ≥3.0 s: HR = 0.43 (95% CI: 0.06–3.20); p = 0.41. Sixteen percent of patients with pauses underwent pacemaker implantation during follow-up. Only pauses in patients referred to Holter due to syncope and/or dizzy spells were associated with an increased risk of pacemaker treatment: HR = 4.7 (95% CI: 1.4–15.9), p = 0.014, adjusted for age, sex, and rate-limiting medication. Conclusion: In patients with AF, prolonged electrocardiographic pauses of ≥2.5 s or ≥3.0 s are not a marker for increased mortality in this real-life clinical study.
AB - Background: In patients with atrial fibrillation (AF), the long-term prognosis of long electrocardiographic pauses in the ventricular action is not well studied. Methods: Consecutive Holter recordings in patients with AF (n = 200) between 2009 and 2011 were evaluated, focusing on pauses of at least 2.5 s. Outcomes of interest were all-cause mortality and pacemaker implantation. Results: Forty-three patients (21.5%) had pauses with a mean of 3.2 s and an SD of 0.9 s. After a median follow-up of 99 months (ranging 89–111), 47% (20/43) of the patients with and 45% (70/157) without pauses were deceased. Pauses of ≥2.5 s did not constitute a risk of increased mortality: HR = 0.75 (95% CI: 0.34–1.66); p = 0.48, neither did pauses of ≥3.0 s: HR = 0.43 (95% CI: 0.06–3.20); p = 0.41. Sixteen percent of patients with pauses underwent pacemaker implantation during follow-up. Only pauses in patients referred to Holter due to syncope and/or dizzy spells were associated with an increased risk of pacemaker treatment: HR = 4.7 (95% CI: 1.4–15.9), p = 0.014, adjusted for age, sex, and rate-limiting medication. Conclusion: In patients with AF, prolonged electrocardiographic pauses of ≥2.5 s or ≥3.0 s are not a marker for increased mortality in this real-life clinical study.
U2 - 10.1159/000520183
DO - 10.1159/000520183
M3 - Journal article
C2 - 34662878
VL - 147
SP - 57
EP - 61
JO - Cardiologia
JF - Cardiologia
SN - 0008-6312
ER -
ID: 303688925