Arachidonic acid metabolism in neutrophil granulocytes obtained from synovial fluid in rheumatoid arthritis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Arachidonic acid metabolism in neutrophil granulocytes obtained from synovial fluid in rheumatoid arthritis. / Langholz, E; Nielsen, O H; Ahnfelt-Rønne, I; Elmgreen, J.

In: Scandinavian Journal of Rheumatology, Vol. 19, No. 6, 1990, p. 387-91.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Langholz, E, Nielsen, OH, Ahnfelt-Rønne, I & Elmgreen, J 1990, 'Arachidonic acid metabolism in neutrophil granulocytes obtained from synovial fluid in rheumatoid arthritis', Scandinavian Journal of Rheumatology, vol. 19, no. 6, pp. 387-91.

APA

Langholz, E., Nielsen, O. H., Ahnfelt-Rønne, I., & Elmgreen, J. (1990). Arachidonic acid metabolism in neutrophil granulocytes obtained from synovial fluid in rheumatoid arthritis. Scandinavian Journal of Rheumatology, 19(6), 387-91.

Vancouver

Langholz E, Nielsen OH, Ahnfelt-Rønne I, Elmgreen J. Arachidonic acid metabolism in neutrophil granulocytes obtained from synovial fluid in rheumatoid arthritis. Scandinavian Journal of Rheumatology. 1990;19(6):387-91.

Author

Langholz, E ; Nielsen, O H ; Ahnfelt-Rønne, I ; Elmgreen, J. / Arachidonic acid metabolism in neutrophil granulocytes obtained from synovial fluid in rheumatoid arthritis. In: Scandinavian Journal of Rheumatology. 1990 ; Vol. 19, No. 6. pp. 387-91.

Bibtex

@article{80d1900f3be74ef9b95fb3af50a0b3ff,
title = "Arachidonic acid metabolism in neutrophil granulocytes obtained from synovial fluid in rheumatoid arthritis",
abstract = "Circulating human neutrophil granulocytes (PMNs) from patients with rheumatoid arthritis (RA) have earlier been described to possess an enhanced capacity for production of certain 5-lipoxygenase-derived metabolites of arachidonic acid (AA), 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). In the present investigation the endogenous AA metabolism of synovial fluid PMNs of RA patients was studied and compared with that of the corresponding circulating PMNs. Synovial fluid PMNs prelabelled with 14C-AA released significantly less radioactivity than circulating PMNs when stimulated with calcium ionophore. Furthermore, synovial fluid PMNs produced significantly smaller amounts of both 5-HETE and LTB4 than circulating PMNs from the same patients, whereas no such difference was observed in the LTB4 catabolites or the cyclo-oxygenase products. More information dealing with the complex way in which arachidonic acid is metabolized in diseased RA joints may provide future rational approaches in the treatment of this chronic inflammatory disease.",
keywords = "Adult, Aged, Arachidonic Acids/metabolism, Arthritis, Rheumatoid/blood, Female, Humans, Hydroxyeicosatetraenoic Acids/blood, Leukotriene B4/blood, Male, Middle Aged, Neutrophils/metabolism, Synovial Fluid/cytology",
author = "E Langholz and Nielsen, {O H} and I Ahnfelt-R{\o}nne and J Elmgreen",
year = "1990",
language = "English",
volume = "19",
pages = "387--91",
journal = "Scandinavian Journal of Rheumatology",
issn = "0300-9742",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - Arachidonic acid metabolism in neutrophil granulocytes obtained from synovial fluid in rheumatoid arthritis

AU - Langholz, E

AU - Nielsen, O H

AU - Ahnfelt-Rønne, I

AU - Elmgreen, J

PY - 1990

Y1 - 1990

N2 - Circulating human neutrophil granulocytes (PMNs) from patients with rheumatoid arthritis (RA) have earlier been described to possess an enhanced capacity for production of certain 5-lipoxygenase-derived metabolites of arachidonic acid (AA), 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). In the present investigation the endogenous AA metabolism of synovial fluid PMNs of RA patients was studied and compared with that of the corresponding circulating PMNs. Synovial fluid PMNs prelabelled with 14C-AA released significantly less radioactivity than circulating PMNs when stimulated with calcium ionophore. Furthermore, synovial fluid PMNs produced significantly smaller amounts of both 5-HETE and LTB4 than circulating PMNs from the same patients, whereas no such difference was observed in the LTB4 catabolites or the cyclo-oxygenase products. More information dealing with the complex way in which arachidonic acid is metabolized in diseased RA joints may provide future rational approaches in the treatment of this chronic inflammatory disease.

AB - Circulating human neutrophil granulocytes (PMNs) from patients with rheumatoid arthritis (RA) have earlier been described to possess an enhanced capacity for production of certain 5-lipoxygenase-derived metabolites of arachidonic acid (AA), 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). In the present investigation the endogenous AA metabolism of synovial fluid PMNs of RA patients was studied and compared with that of the corresponding circulating PMNs. Synovial fluid PMNs prelabelled with 14C-AA released significantly less radioactivity than circulating PMNs when stimulated with calcium ionophore. Furthermore, synovial fluid PMNs produced significantly smaller amounts of both 5-HETE and LTB4 than circulating PMNs from the same patients, whereas no such difference was observed in the LTB4 catabolites or the cyclo-oxygenase products. More information dealing with the complex way in which arachidonic acid is metabolized in diseased RA joints may provide future rational approaches in the treatment of this chronic inflammatory disease.

KW - Adult

KW - Aged

KW - Arachidonic Acids/metabolism

KW - Arthritis, Rheumatoid/blood

KW - Female

KW - Humans

KW - Hydroxyeicosatetraenoic Acids/blood

KW - Leukotriene B4/blood

KW - Male

KW - Middle Aged

KW - Neutrophils/metabolism

KW - Synovial Fluid/cytology

M3 - Journal article

C2 - 2175453

VL - 19

SP - 387

EP - 391

JO - Scandinavian Journal of Rheumatology

JF - Scandinavian Journal of Rheumatology

SN - 0300-9742

IS - 6

ER -

ID: 218728431