Antimicrobial prophylaxis in companion animal surgery: A scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines
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Antimicrobial prophylaxis in companion animal surgery : A scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines. / Sørensen, T. M.; Scahill, K.; Ruperez, J. Espinel; Olejnik, M.; Swinbourne, F.; Verwilghen, D. R.; Nolff, M. C.; Baines, S.; Marques, C.; Vilen, A.; Duarte, E. L.; Dias, M.; Dewulf, S.; Wichtowska, A.; Valencia, A. Carranza; Pelligand, L.; Broens, E. M.; Toutain, P. L.; Alishani, M.; Brennan, M. L.; Weese, J. S.; Jessen, L. R.; Allerton, F.; from European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines and theESCMID Study Group for Veterinary Microbiology (ESGVM).
In: Veterinary Journal, Vol. 304, 106101, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Antimicrobial prophylaxis in companion animal surgery
T2 - A scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines
AU - Sørensen, T. M.
AU - Scahill, K.
AU - Ruperez, J. Espinel
AU - Olejnik, M.
AU - Swinbourne, F.
AU - Verwilghen, D. R.
AU - Nolff, M. C.
AU - Baines, S.
AU - Marques, C.
AU - Vilen, A.
AU - Duarte, E. L.
AU - Dias, M.
AU - Dewulf, S.
AU - Wichtowska, A.
AU - Valencia, A. Carranza
AU - Pelligand, L.
AU - Broens, E. M.
AU - Toutain, P. L.
AU - Alishani, M.
AU - Brennan, M. L.
AU - Weese, J. S.
AU - Jessen, L. R.
AU - Allerton, F.
AU - from European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines and theESCMID Study Group for Veterinary Microbiology (ESGVM)
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Surgical antimicrobial prophylaxis (SAP) is widely used to reduce the risk of surgical site infections (SSI), but there is uncertainty as to what the proportion of SSI reduction is. Therefore, it is difficult for surgeons to properly weigh the costs, risks and benefits for individual patients when deciding on the use of SAP, making it challenging to promote antimicrobial stewardship in primary practice settings. The objective of this study was to map the veterinary evidence focused on assessing the effect of SAP on SSI development and in order to identify surgical procedures with some research evidence and possible knowledge gaps. In October 2021 and December 2022, Scopus, CAB Abstracts, Web of Science Core Collection, Embase and MEDLINE were systematically searched. Double blinded screening of records was performed to identify studies in companion animals that reported on the use of SAP and SSI rates. Comparative data were available from 34 out of 39123 records screened including: eight randomised controlled trials (RCT), 23 cohort studies (seven prospective and 16 retrospective) and three retrospective case series representing 12476 dogs and cats in total. Extracted data described peri- or post-operative SAP in nine, and 25 studies, respectively. In the eight RCTs evaluating SAP in companion animals, surgical procedure coverage was skewed towards orthopaedic stifle surgeries in referral settings and there was large variation in SAP protocols, SSI definitions and follow-up periods. More standardized data collection and agreement of SSI definitions is needed to build stronger evidence for optimized patient care.
AB - Surgical antimicrobial prophylaxis (SAP) is widely used to reduce the risk of surgical site infections (SSI), but there is uncertainty as to what the proportion of SSI reduction is. Therefore, it is difficult for surgeons to properly weigh the costs, risks and benefits for individual patients when deciding on the use of SAP, making it challenging to promote antimicrobial stewardship in primary practice settings. The objective of this study was to map the veterinary evidence focused on assessing the effect of SAP on SSI development and in order to identify surgical procedures with some research evidence and possible knowledge gaps. In October 2021 and December 2022, Scopus, CAB Abstracts, Web of Science Core Collection, Embase and MEDLINE were systematically searched. Double blinded screening of records was performed to identify studies in companion animals that reported on the use of SAP and SSI rates. Comparative data were available from 34 out of 39123 records screened including: eight randomised controlled trials (RCT), 23 cohort studies (seven prospective and 16 retrospective) and three retrospective case series representing 12476 dogs and cats in total. Extracted data described peri- or post-operative SAP in nine, and 25 studies, respectively. In the eight RCTs evaluating SAP in companion animals, surgical procedure coverage was skewed towards orthopaedic stifle surgeries in referral settings and there was large variation in SAP protocols, SSI definitions and follow-up periods. More standardized data collection and agreement of SSI definitions is needed to build stronger evidence for optimized patient care.
KW - Antimicrobial stewardship
KW - Cats
KW - Dogs
KW - Peri-operative
KW - SAP
KW - SSI
KW - Surgical Site Infection
U2 - 10.1016/j.tvjl.2024.106101
DO - 10.1016/j.tvjl.2024.106101
M3 - Journal article
C2 - 38490359
AN - SCOPUS:85188723035
VL - 304
JO - The Veterinary Journal
JF - The Veterinary Journal
SN - 1090-0233
M1 - 106101
ER -
ID: 390193851