An Important Role for RPRD1B in the Heat Shock Response

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

An Important Role for RPRD1B in the Heat Shock Response. / Cugusi, Simona; Bajpe, Prashanth Kumar; Mitter, Richard; Patel, Harshil; Stewart, Aengus; Svejstrup, Jesper Q.

In: Molecular and Cellular Biology, Vol. 42, No. 10, 2022, p. e0017322.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cugusi, S, Bajpe, PK, Mitter, R, Patel, H, Stewart, A & Svejstrup, JQ 2022, 'An Important Role for RPRD1B in the Heat Shock Response', Molecular and Cellular Biology, vol. 42, no. 10, pp. e0017322. https://doi.org/10.1128/mcb.00173-22

APA

Cugusi, S., Bajpe, P. K., Mitter, R., Patel, H., Stewart, A., & Svejstrup, J. Q. (2022). An Important Role for RPRD1B in the Heat Shock Response. Molecular and Cellular Biology, 42(10), e0017322. https://doi.org/10.1128/mcb.00173-22

Vancouver

Cugusi S, Bajpe PK, Mitter R, Patel H, Stewart A, Svejstrup JQ. An Important Role for RPRD1B in the Heat Shock Response. Molecular and Cellular Biology. 2022;42(10):e0017322. https://doi.org/10.1128/mcb.00173-22

Author

Cugusi, Simona ; Bajpe, Prashanth Kumar ; Mitter, Richard ; Patel, Harshil ; Stewart, Aengus ; Svejstrup, Jesper Q. / An Important Role for RPRD1B in the Heat Shock Response. In: Molecular and Cellular Biology. 2022 ; Vol. 42, No. 10. pp. e0017322.

Bibtex

@article{f7f0d93ceeb44c33b5faf936cfd360bb,
title = "An Important Role for RPRD1B in the Heat Shock Response",
abstract = "During the heat shock response (HSR), heat shock factor (HSF1 in mammals) binds to target gene promoters, resulting in increased expression of heat shock proteins that help maintain protein homeostasis and ensure cell survival. Besides HSF1, only a relatively few transcription factors with a specific role in ensuring correctly regulated gene expression during the HSR have been described. Here, we use proteomic and genomic (CRISPR) screening to identify a role for RPRD1B in the response to heat shock. Indeed, cells depleted for RPRD1B are heat shock sensitive and show decreased expression of key heat shock proteins (HSPs). These results add to our understanding of the connection between basic gene expression mechanisms and the HSR.",
keywords = "heat shock, HSF, HSF1, RNA polymerase II, RPRD1B, transcription",
author = "Simona Cugusi and Bajpe, {Prashanth Kumar} and Richard Mitter and Harshil Patel and Aengus Stewart and Svejstrup, {Jesper Q.}",
year = "2022",
doi = "10.1128/mcb.00173-22",
language = "English",
volume = "42",
pages = "e0017322",
journal = "Molecular and Cellular Biology",
issn = "0270-7306",
publisher = "American Society for Microbiology",
number = "10",

}

RIS

TY - JOUR

T1 - An Important Role for RPRD1B in the Heat Shock Response

AU - Cugusi, Simona

AU - Bajpe, Prashanth Kumar

AU - Mitter, Richard

AU - Patel, Harshil

AU - Stewart, Aengus

AU - Svejstrup, Jesper Q.

PY - 2022

Y1 - 2022

N2 - During the heat shock response (HSR), heat shock factor (HSF1 in mammals) binds to target gene promoters, resulting in increased expression of heat shock proteins that help maintain protein homeostasis and ensure cell survival. Besides HSF1, only a relatively few transcription factors with a specific role in ensuring correctly regulated gene expression during the HSR have been described. Here, we use proteomic and genomic (CRISPR) screening to identify a role for RPRD1B in the response to heat shock. Indeed, cells depleted for RPRD1B are heat shock sensitive and show decreased expression of key heat shock proteins (HSPs). These results add to our understanding of the connection between basic gene expression mechanisms and the HSR.

AB - During the heat shock response (HSR), heat shock factor (HSF1 in mammals) binds to target gene promoters, resulting in increased expression of heat shock proteins that help maintain protein homeostasis and ensure cell survival. Besides HSF1, only a relatively few transcription factors with a specific role in ensuring correctly regulated gene expression during the HSR have been described. Here, we use proteomic and genomic (CRISPR) screening to identify a role for RPRD1B in the response to heat shock. Indeed, cells depleted for RPRD1B are heat shock sensitive and show decreased expression of key heat shock proteins (HSPs). These results add to our understanding of the connection between basic gene expression mechanisms and the HSR.

KW - heat shock

KW - HSF

KW - HSF1

KW - RNA polymerase II

KW - RPRD1B

KW - transcription

U2 - 10.1128/mcb.00173-22

DO - 10.1128/mcb.00173-22

M3 - Journal article

C2 - 36121223

AN - SCOPUS:85140416639

VL - 42

SP - e0017322

JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

SN - 0270-7306

IS - 10

ER -

ID: 324316062