Alveolar damage in AIDS-related Pneumocystis carinii pneumonia.

Research output: Contribution to journal › Journal article › Research

Standard

Alveolar damage in AIDS-related Pneumocystis carinii pneumonia. / Benfield, T L; Prentø, P; Junge, Jette; Vestbo, Jørgen; Lundgren, Jens Dilling.

In: Chest, Vol. 111, No. 5, 1997, p. 1193-1199.

Research output: Contribution to journal › Journal article › Research

Harvard

Benfield, TL, Prentø, P, Junge, J, Vestbo, J & Lundgren, JD 1997, 'Alveolar damage in AIDS-related Pneumocystis carinii pneumonia.', Chest, vol. 111, no. 5, pp. 1193-1199. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9149569&query_hl=21>

APA

Benfield, T. L., Prentø, P., Junge, J., Vestbo, J., & Lundgren, J. D. (1997). Alveolar damage in AIDS-related Pneumocystis carinii pneumonia. Chest, 111(5), 1193-1199. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9149569&query_hl=21

Vancouver

Benfield TL, Prentø P, Junge J, Vestbo J, Lundgren JD. Alveolar damage in AIDS-related Pneumocystis carinii pneumonia. Chest. 1997;111(5):1193-1199.

Author

Benfield, T L ; Prentø, P ; Junge, Jette ; Vestbo, Jørgen ; Lundgren, Jens Dilling. / Alveolar damage in AIDS-related Pneumocystis carinii pneumonia. In: Chest. 1997 ; Vol. 111, No. 5. pp. 1193-1199.

Bibtex

@article{eaac559dddd845b1a259592f0be54762,
title = "Alveolar damage in AIDS-related Pneumocystis carinii pneumonia.",
abstract = "OBJECTIVE: Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specimens to compare pathologic features of P carinii pneumonia and other HIV-related lung diseases. DESIGN AND PATIENTS: Thirty-seven consecutive HIV-infected patients undergoing a diagnostic bronchoscopy. RESULTS: P carinii pneumonia was characterized by an increase in inflammation, edema, exudate, fibrosts, type II pneumocyte proliferation, and cellular infiltration of the alveolar wall when compared with other lung diseases (all p < 0.05). Electron microscopy showed apposition of the trophozoite to the type I pneumocyte. Erosion of type I pneumocytes was observed in 13 of 15 patients with P carinii pneumonia, whereas none without P carinii pneumonia had this finding (p < 0.05). Erosion of the type II pneumocyte was not observed. CONCLUSION: Inflammation, interstitial fibrosis, and alveolar epithelial erosion are characteristic features of P carinii pneumonia. The changes may form the pathologic basis for the respiratory failure seen in patients with P carinii pneumonia. Electron microscopy did not show any diagnostie advantage over conventional light microscopy using routine stains.",
author = "Benfield, {T L} and P Prent{\o} and Jette Junge and J{\o}rgen Vestbo and Lundgren, {Jens Dilling}",
year = "1997",
language = "English",
volume = "111",
pages = "1193--1199",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "5",

}

RIS

TY - JOUR

T1 - Alveolar damage in AIDS-related Pneumocystis carinii pneumonia.

AU - Benfield, T L

AU - Prentø, P

AU - Junge, Jette

AU - Vestbo, Jørgen

AU - Lundgren, Jens Dilling

PY - 1997

Y1 - 1997

N2 - OBJECTIVE: Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specimens to compare pathologic features of P carinii pneumonia and other HIV-related lung diseases. DESIGN AND PATIENTS: Thirty-seven consecutive HIV-infected patients undergoing a diagnostic bronchoscopy. RESULTS: P carinii pneumonia was characterized by an increase in inflammation, edema, exudate, fibrosts, type II pneumocyte proliferation, and cellular infiltration of the alveolar wall when compared with other lung diseases (all p < 0.05). Electron microscopy showed apposition of the trophozoite to the type I pneumocyte. Erosion of type I pneumocytes was observed in 13 of 15 patients with P carinii pneumonia, whereas none without P carinii pneumonia had this finding (p < 0.05). Erosion of the type II pneumocyte was not observed. CONCLUSION: Inflammation, interstitial fibrosis, and alveolar epithelial erosion are characteristic features of P carinii pneumonia. The changes may form the pathologic basis for the respiratory failure seen in patients with P carinii pneumonia. Electron microscopy did not show any diagnostie advantage over conventional light microscopy using routine stains.

AB - OBJECTIVE: Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specimens to compare pathologic features of P carinii pneumonia and other HIV-related lung diseases. DESIGN AND PATIENTS: Thirty-seven consecutive HIV-infected patients undergoing a diagnostic bronchoscopy. RESULTS: P carinii pneumonia was characterized by an increase in inflammation, edema, exudate, fibrosts, type II pneumocyte proliferation, and cellular infiltration of the alveolar wall when compared with other lung diseases (all p < 0.05). Electron microscopy showed apposition of the trophozoite to the type I pneumocyte. Erosion of type I pneumocytes was observed in 13 of 15 patients with P carinii pneumonia, whereas none without P carinii pneumonia had this finding (p < 0.05). Erosion of the type II pneumocyte was not observed. CONCLUSION: Inflammation, interstitial fibrosis, and alveolar epithelial erosion are characteristic features of P carinii pneumonia. The changes may form the pathologic basis for the respiratory failure seen in patients with P carinii pneumonia. Electron microscopy did not show any diagnostie advantage over conventional light microscopy using routine stains.

M3 - Journal article

VL - 111

SP - 1193

EP - 1199

JO - Chest

JF - Chest

SN - 0012-3692

IS - 5

ER -

ID: 34128705