Alterations in ventricular structure and function in obese adolescents with nonalcoholic fatty liver disease
Research output: Contribution to journal › Journal article › Research › peer-review
Objective: To determine the association among nonalcoholic fatty liver disease (NAFLD), metabolic function, and cardiac function in obese adolescents.
Sstudy design: Intrahepatic triglyceride (IHTG) content (magnetic resonance spectroscopy), insulin sensitivity and β-cell function (5-hour oral glucose tolerance test with mathematical modeling), and left ventricular function (speckle tracking echocardiography) were determined in 3 groups of age, sex, and Tanner matched adolescents: (1) lean (n=14, body mass index [BMI]=20±2 kg/m2); (2) obese with normal (2.5%) IHTG content (n=15, BMI=35±3 kg/m2); and (3) obese with increased (8.7%) IHTG content (n=15, BMI=37±6 kg/m2).
Results: The disposition index (β-cell function) and insulin sensitivity index were ∼45% and ∼70% lower, respectively, and whole body insulin resistance, calculated by homeostasis model of assessment-insulin resistance (HOMA-IR), was ∼60% greater, in obese than in lean subjects, and ∼30% and ∼50% lower and ∼150% greater, respectively, in obese subjects with NAFLD than those without NAFLD (P < .05 for all). Left ventricular global longitudinal systolic strain and early diastolic strain rates were significantly decreased in obese than in lean subjects, and in obese subjects with NAFLD than those without NAFLD (P < .05 for all), and were independently associated with HOMA-IR (β=0.634). IHTG content was the only significant independent determinant of insulin sensitivity index (β = -0.770), disposition index (β = -0.651), and HOMA-IR (β = 0.738).
Conclusions: These findings demonstrate that the presence of NAFLD in otherwise asymptomatic obese adolescents is an early marker of cardiac dysfunction.
Original language | English |
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Journal | Journal of Pediatrics |
Volume | 162 |
Issue number | 6 |
Pages (from-to) | 1160-1168 + 1168.e1 |
Number of pages | 10 |
ISSN | 0022-3476 |
DOIs | |
Publication status | Published - 2013 |
Externally published | Yes |
Bibliographical note
Copyright © 2013 Mosby, Inc. All rights reserved.
- Adolescent, Body Mass Index, Cross-Sectional Studies, Fatty Liver/metabolism, Female, Heart Ventricles/pathology, Humans, Insulin Resistance, Liver/metabolism, Magnetic Resonance Spectroscopy, Male, Non-alcoholic Fatty Liver Disease, Obesity/complications, Triglycerides/metabolism
Research areas
ID: 289973265