Alcohol, smoking and benign hepato-biliary disease
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Alcohol, smoking and benign hepato-biliary disease. / Shabanzadeh, Daniel Mønsted; Novovic, Srdan.
In: Best Practice and Research: Clinical Gastroenterology, Vol. 31, No. 5, 10.2017, p. 519-527.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Alcohol, smoking and benign hepato-biliary disease
AU - Shabanzadeh, Daniel Mønsted
AU - Novovic, Srdan
PY - 2017/10
Y1 - 2017/10
N2 - Gallstone disease and pancreatitis are the most frequent benign hepato-biliary causes of hospital admissions. Gallstone disease is prevalent, but symptomatic disease develops only in about one out of five carriers. Alcohol intake seems to protect gallstone formation in cohort studies possibly through effects on bile cholesterol metabolism, the enterohepatic circulation, and gallbladder function. The impact of smoking on gallstone formation seems minor. Both alcohol intake and smoking do not alter the clinical course of gallstone disease carriers. Cholecystectomy is the preferred treatment for symptomatic gallstone disease. Studies about the impact of alcohol and smoking on the post-cholecystectomy state are few and future studies should be performed. Pancreatitis is associated with both excessive alcohol intake and smoking in observational studies. Interpretation of associations with pancreatitis is hampered by an incomplete understanding of underlying mechanisms and by the co-existence of excessive alcohol intake and smoking. Smoking cessation and alcohol abstinence is recommended in the treatment of pancreatitis, but higher-level evidence is needed.
AB - Gallstone disease and pancreatitis are the most frequent benign hepato-biliary causes of hospital admissions. Gallstone disease is prevalent, but symptomatic disease develops only in about one out of five carriers. Alcohol intake seems to protect gallstone formation in cohort studies possibly through effects on bile cholesterol metabolism, the enterohepatic circulation, and gallbladder function. The impact of smoking on gallstone formation seems minor. Both alcohol intake and smoking do not alter the clinical course of gallstone disease carriers. Cholecystectomy is the preferred treatment for symptomatic gallstone disease. Studies about the impact of alcohol and smoking on the post-cholecystectomy state are few and future studies should be performed. Pancreatitis is associated with both excessive alcohol intake and smoking in observational studies. Interpretation of associations with pancreatitis is hampered by an incomplete understanding of underlying mechanisms and by the co-existence of excessive alcohol intake and smoking. Smoking cessation and alcohol abstinence is recommended in the treatment of pancreatitis, but higher-level evidence is needed.
KW - Alcohol drinking
KW - Alcohol-related disorders
KW - Alcoholic
KW - Alcoholism
KW - Cholecystectomy
KW - Cholelithiasis
KW - Chronic
KW - Gallbladder diseases
KW - Gallstones
KW - Laparoscopic
KW - Pancreatitis
KW - Smoking
U2 - 10.1016/j.bpg.2017.09.005
DO - 10.1016/j.bpg.2017.09.005
M3 - Review
C2 - 29195671
AN - SCOPUS:85029154929
VL - 31
SP - 519
EP - 527
JO - Bailliere's Best Practice and Research in Clinical Gastroenterology
JF - Bailliere's Best Practice and Research in Clinical Gastroenterology
SN - 1521-6918
IS - 5
ER -
ID: 189697573