TY - JOUR

T1 - Affective lability in parents with schizophrenia or bipolar disorder and their co-parents - The Danish High Risk and Resilience Study VIA 7

AU - Steffensen, Nanna Lawaetz

AU - Hemager, Nicoline

AU - Bundgaard, Anette Faurskov

AU - Gantriis, Ditte Lou

AU - Burton, Birgitte Klee

AU - Ellersgaard, Ditte

AU - Carlsen, Anders Helles

AU - Bliksted, Vibeke

AU - Plessen, Kerstin J.

AU - Jepsen, Jens Richardt Møllegaard

AU - Nordentoft, Merete

AU - Thorup, Anne A.E.

AU - Mors, Ole

AU - Greve, Aja Neergaard

N1 - Publisher Copyright: © 2023 The Author(s)

PY - 2023

Y1 - 2023

N2 - In bipolar disorder, dysregulation of affect is a core feature while knowledge on affective lability in schizophrenia is sparse. Research on affective lability in partners to individuals with schizophrenia or bipolar disorder is also lacking. The objective of this study was to investigate affective lability in parents with schizophrenia or bipolar disorder, and their co-parents without these disorders. The Danish High Risk and Resilience Study – VIA 7 is a population-based cohort study. This study focuses on parents diagnosed with schizophrenia (n = 148), their co-parents (n = 157), parents with bipolar disorder (n = 98), their co-parents (n = 89) and control parents (n = 359). The Affective Lability Scale – short form (ALS-SF) was used to measure affective lability. We found significantly higher levels of affective lability in parents with schizophrenia and bipolar disorder compared with controls, but no significant differences between bipolar disorder and schizophrenia. Co-parents to parents with schizophrenia had significantly higher levels of affective lability compared to controls. Our results add to the existing knowledge concerning underlying transdiagnostic factors and nonrandom mating in schizophrenia and bipolar disorder and highlight the need for studies of parental affective lability as a potential risk factor for offspring in families with parental schizophrenia or bipolar disorder.

AB - In bipolar disorder, dysregulation of affect is a core feature while knowledge on affective lability in schizophrenia is sparse. Research on affective lability in partners to individuals with schizophrenia or bipolar disorder is also lacking. The objective of this study was to investigate affective lability in parents with schizophrenia or bipolar disorder, and their co-parents without these disorders. The Danish High Risk and Resilience Study – VIA 7 is a population-based cohort study. This study focuses on parents diagnosed with schizophrenia (n = 148), their co-parents (n = 157), parents with bipolar disorder (n = 98), their co-parents (n = 89) and control parents (n = 359). The Affective Lability Scale – short form (ALS-SF) was used to measure affective lability. We found significantly higher levels of affective lability in parents with schizophrenia and bipolar disorder compared with controls, but no significant differences between bipolar disorder and schizophrenia. Co-parents to parents with schizophrenia had significantly higher levels of affective lability compared to controls. Our results add to the existing knowledge concerning underlying transdiagnostic factors and nonrandom mating in schizophrenia and bipolar disorder and highlight the need for studies of parental affective lability as a potential risk factor for offspring in families with parental schizophrenia or bipolar disorder.

KW - Assortative mating

KW - Bipolar disorder

KW - Mental disorders

KW - Nonrandom mating

KW - Parents

KW - Schizophrenia

U2 - 10.1016/j.psychres.2023.115092

DO - 10.1016/j.psychres.2023.115092

M3 - Journal article

C2 - 36773417

AN - SCOPUS:85147802288

VL - 321

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

M1 - 115092

ER -