Adrenaline-induced mobilization of T cells in HIV-infected patients
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Adrenaline-induced mobilization of T cells in HIV-infected patients. / Søndergaard, S R; Cozzi-Lepri, A; Ullum, H; Wiis, J; Hermann, C K; Laursen, S B; Qvist, J; Gerstoft, J; Skinhøj, P; Pedersen, Bente Klarlund.
In: Clinical and Experimental Immunology, Vol. 119, No. 1, 01.2000, p. 115-22.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Adrenaline-induced mobilization of T cells in HIV-infected patients
AU - Søndergaard, S R
AU - Cozzi-Lepri, A
AU - Ullum, H
AU - Wiis, J
AU - Hermann, C K
AU - Laursen, S B
AU - Qvist, J
AU - Gerstoft, J
AU - Skinhøj, P
AU - Pedersen, Bente Klarlund
PY - 2000/1
Y1 - 2000/1
N2 - The present study aimed to investigate lymphocyte mobilization from peripheral cell reservoirs in HIV-infected patients. Nine HIV-infected patients on stable highly active anti-retroviral therapy (HAART), eight treatment-naive HIV-infected patients and eight HIV- controls received a 1-h adrenaline infusion. The adrenaline infusion induced a three-fold increase in the concentration of lymphocytes in all three groups. All HIV-infected patients mobilized significantly higher numbers of CD8+ cells but less CD4+ cells. All subjects mobilized CD45RA+CD62L+ and CD8+CD28+ cells to a lesser extent than CD45RO+CD45RA- and CD8+CD28-cells. Furthermore, high numbers of CD8+CD38+ cells were mobilized only in the HIV-infected patients. It was therefore predominantly T cells with an activated phenotype which were mobilized after adrenaline stimulation. It is concluded that the HIV-associated immune defect induced an impaired ability to mobilize immune-competent cells in response to stress stimuli. Furthermore, the study does not support the idea that CD4+ T cells are trapped in lymph nodes by HIV antigens, because untreated and HAART-treated HIV-infected patients mobilized similar numbers of CD4+ T cells. Finally, no evidence was found for the existence of a HAART-induced non-circulating pool of CD4+ T cells.
AB - The present study aimed to investigate lymphocyte mobilization from peripheral cell reservoirs in HIV-infected patients. Nine HIV-infected patients on stable highly active anti-retroviral therapy (HAART), eight treatment-naive HIV-infected patients and eight HIV- controls received a 1-h adrenaline infusion. The adrenaline infusion induced a three-fold increase in the concentration of lymphocytes in all three groups. All HIV-infected patients mobilized significantly higher numbers of CD8+ cells but less CD4+ cells. All subjects mobilized CD45RA+CD62L+ and CD8+CD28+ cells to a lesser extent than CD45RO+CD45RA- and CD8+CD28-cells. Furthermore, high numbers of CD8+CD38+ cells were mobilized only in the HIV-infected patients. It was therefore predominantly T cells with an activated phenotype which were mobilized after adrenaline stimulation. It is concluded that the HIV-associated immune defect induced an impaired ability to mobilize immune-competent cells in response to stress stimuli. Furthermore, the study does not support the idea that CD4+ T cells are trapped in lymph nodes by HIV antigens, because untreated and HAART-treated HIV-infected patients mobilized similar numbers of CD4+ T cells. Finally, no evidence was found for the existence of a HAART-induced non-circulating pool of CD4+ T cells.
KW - ADP-ribosyl Cyclase
KW - Adult
KW - Anti-HIV Agents
KW - Antigens, CD
KW - Antigens, CD28
KW - Antigens, CD38
KW - Antigens, Differentiation
KW - CD4-Positive T-Lymphocytes
KW - CD8-Positive T-Lymphocytes
KW - Case-Control Studies
KW - Epinephrine
KW - Female
KW - HIV Infections
KW - Humans
KW - Male
KW - Membrane Glycoproteins
KW - Middle Aged
KW - NAD+ Nucleosidase
KW - T-Lymphocyte Subsets
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - Journal article
C2 - 10606972
VL - 119
SP - 115
EP - 122
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
SN - 0009-9104
IS - 1
ER -
ID: 180572066