Administration of platelets to ruptured abdominal aortic aneurysm patients before open surgery: a prospective, single-blinded, randomised study
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Administration of platelets to ruptured abdominal aortic aneurysm patients before open surgery : a prospective, single-blinded, randomised study. / Lunen, T B; Johansson, P I; Jensen, L P; Homburg, K M; Roeder, O C; Lonn, L; Secher, N H; Helgstrand, U; Carstensen, M; Jensen, K B; Lange, T; Sillesen, H; Swiatek, F; Nielsen, H B.
In: Transfusion Medicine, Vol. 28, No. 5, 2018, p. 386-391.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Administration of platelets to ruptured abdominal aortic aneurysm patients before open surgery
T2 - a prospective, single-blinded, randomised study
AU - Lunen, T B
AU - Johansson, P I
AU - Jensen, L P
AU - Homburg, K M
AU - Roeder, O C
AU - Lonn, L
AU - Secher, N H
AU - Helgstrand, U
AU - Carstensen, M
AU - Jensen, K B
AU - Lange, T
AU - Sillesen, H
AU - Swiatek, F
AU - Nielsen, H B
N1 - © 2018 British Blood Transfusion Society.
PY - 2018
Y1 - 2018
N2 - BACKGROUND: In patients undergoing open surgery for a ruptured abdominal aortic aneurysm (rAAA), survivors demonstrate a high platelet count, and proactive administration of platelets (and fresh frozen plasma) appears to influence mortality.OBJECTIVES: This trial investigated the effect of platelets administered before transport to surgery.METHODS: In a prospective study design, patients were randomised to receive platelets (intervention; n = 61) or no platelets (control; n = 61) before transport to vascular surgery from 11 local hospitals. The study was terminated when one of the vascular surgical centres implemented endovascular repair for rAAA patients.RESULTS: Thirty days after surgery, mortality was 36% for patients with intervention vs 31% for controls (P = 0·32). Post-operative thrombotic events (14 vs 15; P = 0·69), renal failure (11 vs 10; P = 0·15) and pulmonary insufficiency (34 vs 39; P = 0·15) were similar in the two groups of patients. No adverse reactions to platelet administration were observed. In addition, length of stay in the intensive care unit was unaffected by intervention.CONCLUSIONS: For patients planned for open repair of a rAAA, we observed no significant effect of early administration of platelets with regard to post-operative complications and stay in the ICU or in hospital and also no significant effect on mortality.
AB - BACKGROUND: In patients undergoing open surgery for a ruptured abdominal aortic aneurysm (rAAA), survivors demonstrate a high platelet count, and proactive administration of platelets (and fresh frozen plasma) appears to influence mortality.OBJECTIVES: This trial investigated the effect of platelets administered before transport to surgery.METHODS: In a prospective study design, patients were randomised to receive platelets (intervention; n = 61) or no platelets (control; n = 61) before transport to vascular surgery from 11 local hospitals. The study was terminated when one of the vascular surgical centres implemented endovascular repair for rAAA patients.RESULTS: Thirty days after surgery, mortality was 36% for patients with intervention vs 31% for controls (P = 0·32). Post-operative thrombotic events (14 vs 15; P = 0·69), renal failure (11 vs 10; P = 0·15) and pulmonary insufficiency (34 vs 39; P = 0·15) were similar in the two groups of patients. No adverse reactions to platelet administration were observed. In addition, length of stay in the intensive care unit was unaffected by intervention.CONCLUSIONS: For patients planned for open repair of a rAAA, we observed no significant effect of early administration of platelets with regard to post-operative complications and stay in the ICU or in hospital and also no significant effect on mortality.
KW - Aged
KW - Aortic Aneurysm, Abdominal/mortality
KW - Aortic Rupture/mortality
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Platelet Transfusion
KW - Postoperative Complications
KW - Prospective Studies
KW - Vascular Surgical Procedures/mortality
U2 - 10.1111/tme.12540
DO - 10.1111/tme.12540
M3 - Journal article
C2 - 29781549
VL - 28
SP - 386
EP - 391
JO - Transfusion Medicine
JF - Transfusion Medicine
SN - 0958-7578
IS - 5
ER -
ID: 218611438