Adhesions, infl ammatory response and foreign body giant cells infi ltration of the topical hemostats TachoSil®, Hemopatch™ and Veriset™: An Animal Study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Adhesions, infl ammatory response and foreign body giant cells infi ltration of the topical hemostats TachoSil®, Hemopatch™ and Veriset™ : An Animal Study. / Schiøtt Nissen, Line; Hunter, Jacob; Schrøder, Henrik Daa; Rütz, Kenneth; Bollen, Peter.

In: Journal of Surgery and Surgical Research, Vol. 3, No. 2, 2017, p. 38-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schiøtt Nissen, L, Hunter, J, Schrøder, HD, Rütz, K & Bollen, P 2017, 'Adhesions, infl ammatory response and foreign body giant cells infi ltration of the topical hemostats TachoSil®, Hemopatch™ and Veriset™: An Animal Study', Journal of Surgery and Surgical Research, vol. 3, no. 2, pp. 38-41. https://doi.org/10.17352/2455-2968.000043

APA

Schiøtt Nissen, L., Hunter, J., Schrøder, H. D., Rütz, K., & Bollen, P. (2017). Adhesions, infl ammatory response and foreign body giant cells infi ltration of the topical hemostats TachoSil®, Hemopatch™ and Veriset™: An Animal Study. Journal of Surgery and Surgical Research, 3(2), 38-41. https://doi.org/10.17352/2455-2968.000043

Vancouver

Schiøtt Nissen L, Hunter J, Schrøder HD, Rütz K, Bollen P. Adhesions, infl ammatory response and foreign body giant cells infi ltration of the topical hemostats TachoSil®, Hemopatch™ and Veriset™: An Animal Study. Journal of Surgery and Surgical Research. 2017;3(2):38-41. https://doi.org/10.17352/2455-2968.000043

Author

Schiøtt Nissen, Line ; Hunter, Jacob ; Schrøder, Henrik Daa ; Rütz, Kenneth ; Bollen, Peter. / Adhesions, infl ammatory response and foreign body giant cells infi ltration of the topical hemostats TachoSil®, Hemopatch™ and Veriset™ : An Animal Study. In: Journal of Surgery and Surgical Research. 2017 ; Vol. 3, No. 2. pp. 38-41.

Bibtex

@article{441b87d09f3f409d8aeb057475fa3262,
title = "Adhesions, infl ammatory response and foreign body giant cells infi ltration of the topical hemostats TachoSil{\textregistered}, Hemopatch{\texttrademark} and Veriset{\texttrademark}: An Animal Study",
abstract = "Background: When liver bleeding cannot be controlled by conventional methods, a topical hemostatic patch can be applied during surgery. In recent years new hemostats have become available. The aim of this study was to investigate the degree of adhesion and inflammation for three topical hemostatic patches, TachoSil{\textregistered}, Hemopatch{\texttrademark} and Veriset{\texttrademark}. Methods: In 60 adult male Sprague Dawley rats liver two lesions were induced with a scalpel. Each rat was treated with two of the three patches tested. After 1, 2 and 3 months the animals were euthanized and macroscopic evaluation of adhesions and histological assessment of inflammation and macrophage infiltration were performed. Results: A significant higher (p<0.05) occurrence of foreign body giant cells (FBGCs) was found in Hemopatch{\texttrademark} and Veriset{\texttrademark}, whereas both had a lower degree of inflammatory and macrophage infiltration compared to TachoSil{\textregistered}. No differences in the occurrence of adhesions were found. Conclusion: Our study found evidence for difference in inflammation and formation of foreign body giant cells for the three hemostatic patches.",
keywords = "Hemostatical patch; In fl ammatory response; Animal study",
author = "{Schi{\o}tt Nissen}, Line and Jacob Hunter and Schr{\o}der, {Henrik Daa} and Kenneth R{\"u}tz and Peter Bollen",
year = "2017",
doi = "10.17352/2455-2968.000043",
language = "English",
volume = "3",
pages = "38--41",
journal = "Journal of Surgery and Surgical Research",
issn = "2455-2968",
publisher = "Peertechz Publications Private Limited",
number = "2",

}

RIS

TY - JOUR

T1 - Adhesions, infl ammatory response and foreign body giant cells infi ltration of the topical hemostats TachoSil®, Hemopatch™ and Veriset™

T2 - An Animal Study

AU - Schiøtt Nissen, Line

AU - Hunter, Jacob

AU - Schrøder, Henrik Daa

AU - Rütz, Kenneth

AU - Bollen, Peter

PY - 2017

Y1 - 2017

N2 - Background: When liver bleeding cannot be controlled by conventional methods, a topical hemostatic patch can be applied during surgery. In recent years new hemostats have become available. The aim of this study was to investigate the degree of adhesion and inflammation for three topical hemostatic patches, TachoSil®, Hemopatch™ and Veriset™. Methods: In 60 adult male Sprague Dawley rats liver two lesions were induced with a scalpel. Each rat was treated with two of the three patches tested. After 1, 2 and 3 months the animals were euthanized and macroscopic evaluation of adhesions and histological assessment of inflammation and macrophage infiltration were performed. Results: A significant higher (p<0.05) occurrence of foreign body giant cells (FBGCs) was found in Hemopatch™ and Veriset™, whereas both had a lower degree of inflammatory and macrophage infiltration compared to TachoSil®. No differences in the occurrence of adhesions were found. Conclusion: Our study found evidence for difference in inflammation and formation of foreign body giant cells for the three hemostatic patches.

AB - Background: When liver bleeding cannot be controlled by conventional methods, a topical hemostatic patch can be applied during surgery. In recent years new hemostats have become available. The aim of this study was to investigate the degree of adhesion and inflammation for three topical hemostatic patches, TachoSil®, Hemopatch™ and Veriset™. Methods: In 60 adult male Sprague Dawley rats liver two lesions were induced with a scalpel. Each rat was treated with two of the three patches tested. After 1, 2 and 3 months the animals were euthanized and macroscopic evaluation of adhesions and histological assessment of inflammation and macrophage infiltration were performed. Results: A significant higher (p<0.05) occurrence of foreign body giant cells (FBGCs) was found in Hemopatch™ and Veriset™, whereas both had a lower degree of inflammatory and macrophage infiltration compared to TachoSil®. No differences in the occurrence of adhesions were found. Conclusion: Our study found evidence for difference in inflammation and formation of foreign body giant cells for the three hemostatic patches.

KW - Hemostatical patch; In fl ammatory response; Animal study

U2 - 10.17352/2455-2968.000043

DO - 10.17352/2455-2968.000043

M3 - Journal article

VL - 3

SP - 38

EP - 41

JO - Journal of Surgery and Surgical Research

JF - Journal of Surgery and Surgical Research

SN - 2455-2968

IS - 2

ER -

ID: 323447421