Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjects
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Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjects. / Holmer-Jensen, Jens; Mortensen, Lene Sundahl; Astrup, Arne; de Vrese, Michael; Holst, Jens Juul; Thomsen, Claus; Hermansen, Kjeld.
In: Nutrition Research, Vol. 33, No. 1, 2013, p. 34-40.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjects
AU - Holmer-Jensen, Jens
AU - Mortensen, Lene Sundahl
AU - Astrup, Arne
AU - de Vrese, Michael
AU - Holst, Jens Juul
AU - Thomsen, Claus
AU - Hermansen, Kjeld
N1 - CURIS 2013 NEXS 067
PY - 2013
Y1 - 2013
N2 - Non-fasting triglyceridemia is much closer associated to cardiovascular risk compared to fasting triglyceridemia. We hypothesized that there would be acute differential effects of four common dietary proteins (cod protein, whey isolate, gluten, and casein) on postprandial lipemia in obese non-diabetic subjects. To test the hypothesis we conducted a randomized, acute clinical intervention study with crossover design. We supplemented a fat rich mixed meal with one of four dietary proteins i.e. cod protein, whey protein, gluten or casein. Eleven obese non-diabetic subjects (age: 40-68, body mass index: 30.3-42.0 kg/m(2)) participated and blood samples were drawn in the 8-h postprandial period. Supplementation of a fat rich mixed meal with whey protein caused lower postprandial lipemia (P = .048) compared to supplementation with cod protein and gluten. This was primarily due to lower triglyceride concentration in the chylomicron rich fraction (P = .0293). Thus, we have demonstrated acute differential effects on postprandial metabolism of four dietary proteins supplemented to a fat rich mixed meal in obese non-diabetic subjects. Supplementation with whey protein caused lower postprandial lipemia compared to supplementation with cod and gluten. As postprandial lipemia is closely correlated to cardiovascular disease, long-term dietary supplementation with whey protein may prove beneficial in preventing cardiovascular disease in obese non-diabetic subjects.
AB - Non-fasting triglyceridemia is much closer associated to cardiovascular risk compared to fasting triglyceridemia. We hypothesized that there would be acute differential effects of four common dietary proteins (cod protein, whey isolate, gluten, and casein) on postprandial lipemia in obese non-diabetic subjects. To test the hypothesis we conducted a randomized, acute clinical intervention study with crossover design. We supplemented a fat rich mixed meal with one of four dietary proteins i.e. cod protein, whey protein, gluten or casein. Eleven obese non-diabetic subjects (age: 40-68, body mass index: 30.3-42.0 kg/m(2)) participated and blood samples were drawn in the 8-h postprandial period. Supplementation of a fat rich mixed meal with whey protein caused lower postprandial lipemia (P = .048) compared to supplementation with cod protein and gluten. This was primarily due to lower triglyceride concentration in the chylomicron rich fraction (P = .0293). Thus, we have demonstrated acute differential effects on postprandial metabolism of four dietary proteins supplemented to a fat rich mixed meal in obese non-diabetic subjects. Supplementation with whey protein caused lower postprandial lipemia compared to supplementation with cod and gluten. As postprandial lipemia is closely correlated to cardiovascular disease, long-term dietary supplementation with whey protein may prove beneficial in preventing cardiovascular disease in obese non-diabetic subjects.
U2 - 10.1016/j.nutres.2012.11.004
DO - 10.1016/j.nutres.2012.11.004
M3 - Journal article
C2 - 23351408
VL - 33
SP - 34
EP - 40
JO - Nutrition Research
JF - Nutrition Research
SN - 0271-5317
IS - 1
ER -
ID: 44866205